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小木虫论坛-学术科研互动平台» 网络生活区» 有奖问答 » 有奖问答完结子版 » 【求助】 sci 翻译 英译汉
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[求助] 【求助】 sci 翻译 英译汉

3.5.2. The effect of SFP in the hot plate test
After administration (i.g.) of physiological saline, aspirin and
three doses of SFP, respectively, the baseline latency was examined
at 15 min, 30 min, 45 min and 120 min. The results showed
that SFP at low dose (0.3 g/kg) did not produce a significant
analgesic effect. The latency of Asprin (250 mg/kg) showed
20.48 ± 2.10% at 15 min, and middle dose (1.5 g/kg) and high dose
(3.0 g/kg) of SFP at 15 (79.55 ± 2.48%; 55.09 ± 8.20%) and 120 min
(66.42 ± 16.6%; 64.73 ± 10.54%) meant they produced significant
analgesic response (Fig. 5).
Previous published researches showed that, after continuous
administration for 7 days, SFP was able to inhibit pathological pain
caused by two different chemical stimulations, potassium antimony
tartrate and formalin [19]. However, various tests, such as
the formalin test, tail-flick test, hot-plate test and writhing test produced
different profiles of sensitivity in the analgesic activity tests,
so that it was better to combine them to obtain a comprehensive
evaluation of analgesia [20]. In our experiment, SFP obtained by
the optimized technology with high quality checked by UV and IR
was used to investigate its analgesic activity in two models related
to the peripheral and supraspinal mechanism after some modifications
of previous dosage and administration in Refs. [13,19].
The acetic acid-induced writhing reaction has long been used as a
screening tool for evaluation of peripheral analgesia because of its
simplicity and sensitivity [21]. In this test, the middle and high dose
SFP (1.5, 3.0 g/kg) produced strong analgesic activity similar to that
of Aspirin. For supraspinal analgesic model, the hot-plate test was
considered to be selective for centrally acting analgesic compounds
and provided further confirmation of the central effect. The results
suggested that middle and high dose (1.5, 3.0 g/kg) of SFP may have
central analgesic properties and be better than that of Aspirin. Our
results showed that the purified SFP played a number of roles in
analgesic activity, which might be related to its known ability of
scavenge oxygen free radicals (OFR) like OH and O2− since the accumulation
of oxygen free radicals (OFR) will increase the amount of
Ca2+ in cells which is known to play a key role during the course of
inducing the pain [22,23].
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3.5.2。 SFP影响电热板测试
将生理盐水,阿司匹林和三个剂量的SFP分别基线延迟检查时间设置为15分钟,30分钟,45分钟和120分钟。结果表明,在低剂量SFP(0.3 g / kg)没有产生显著的镇痛效应。阿司匹林(250毫克/公斤) 的延迟15分钟显示20.48±2.10%；中间剂量(1.5 g / kg)和高剂量(3.0 g / kg)的SFP 15(79.55±2.48%;55.09±8.20%)和120分钟(66.42±16.6%;64.73±10.54%)意味着他们产生显著镇痛反应(图5)。
先前出版的研究表明,在连续用药7天,SFP能够抑制病理性疼痛引起的两个不同的化学刺激、钾酒石酸锑钾和福尔马林[19]。然而,各种镇痛活性测试,如福尔马林试验, 甩尾反射潜伏期测定, 电热板测试和扭体测试得出产生抗翻滚的敏感性不同。所以,最好的方法是获得一个综合镇痛评价 [20]。
在我们的实验中,优化的SFP技术与高质量复核紫外、红外吸收方法,用来考察其镇痛活性在两模型相关的外围和脊椎上的机制，一些修改以前的剂量和管理可参考文献 [13、19)。醋酸的酸诱导扭体法长期以来一直被用来作为筛查工具作周边镇痛由于其简单性和敏感性的评估[21]。
在这个测试中,中、高剂量SFP(1.5、3.0 g / kg)产生了强烈的镇痛活性类似阿司匹林。对于脊椎上的镇痛模型,抗试验被认为是选择性的中枢作用镇痛化合物和提供了进一步确认中央效应。结果表明,中、高剂量(1.5、3.0 g / kg)的SFP可能中央镇痛属性和比这更好的阿司匹林。我们的结果表明,纯化SFP在镇痛活性中扮演了多个角色,这可能与它的已知的清除氧自由基的能力(氧自由基)比如OH/O2−自氧自由基,积累的氧自由基将增加Ca2 +在细胞中的数量，这是诱导疼痛过程中发挥关键作用的因素 (22、23)。
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