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铜虫 (小有名气)

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[求助] 【求助】 sci 翻译英译汉

3.5.2. The effect of SFP in the hot plate test
After administration (i.g.) of physiological saline, aspirin and
three doses of SFP, respectively, the baseline latency was examined
at 15 min, 30 min, 45 min and 120 min. The results showed
that SFP at low dose (0.3 g/kg) did not produce a significant
analgesic effect. The latency of Asprin (250 mg/kg) showed
20.48 ± 2.10% at 15 min, and middle dose (1.5 g/kg) and high dose
(3.0 g/kg) of SFP at 15 (79.55 ± 2.48%; 55.09 ± 8.20%) and 120 min
(66.42 ± 16.6%; 64.73 ± 10.54%) meant they produced significant
analgesic response (Fig. 5).
Previous published researches showed that, after continuous
administration for 7 days, SFP was able to inhibit pathological pain
caused by two different chemical stimulations, potassium antimony
tartrate and formalin [19]. However, various tests, such as
the formalin test, tail-flick test, hot-plate test and writhing test produced
different profiles of sensitivity in the analgesic activity tests,
so that it was better to combine them to obtain a comprehensive
evaluation of analgesia [20]. In our experiment, SFP obtained by
the optimized technology with high quality checked by UV and IR
was used to investigate its analgesic activity in two models related
to the peripheral and supraspinal mechanism after some modifications
of previous dosage and administration in Refs. [13,19].
The acetic acid-induced writhing reaction has long been used as a
screening tool for evaluation of peripheral analgesia because of its
simplicity and sensitivity [21]. In this test, the middle and high dose
SFP (1.5, 3.0 g/kg) produced strong analgesic activity similar to that
of Aspirin. For supraspinal analgesic model, the hot-plate test was
considered to be selective for centrally acting analgesic compounds
and provided further confirmation of the central effect. The results
suggested that middle and high dose (1.5, 3.0 g/kg) of SFP may have
central analgesic properties and be better than that of Aspirin. Our
results showed that the purified SFP played a number of roles in
analgesic activity, which might be related to its known ability of
scavenge oxygen free radicals (OFR) like OH and O2− since the accumulation
of oxygen free radicals (OFR) will increase the amount of
Ca2+ in cells which is known to play a key role during the course of
inducing the pain [22,23].

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