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[求助] 求高人帮忙翻译一下速度啊

The  discriminative  stimulus  (DS)  properties  of
d-amphetamine  (AMP)  are  thought  to  be mediated  by  en-
hanced  release of catecholamines, which may involve neuro-
nal  calcium  influx  through  voltage  sensitive  channels.  The
present study examined  the influence of nimodipine,  a calci-
um  channel  blocker,  on  the  DS  properties  of AMP.  Rats
(N=8)  were  trained  to  discriminate  AMP  (0.5 mg/kg,  IP)
from saline in a  two-lever, food-reinforced, drug discrimina-
tion  paradigm.  Nimodipine  alone  (2.0-5.6 mg/kg,  IP)  did
not  substitute  for AMP.  When  given  in  combination  with
AMP,  2.0 mg/kg  nimodipine  increased  by  less  than  2-fold
the  AMP  dose  necessary  to  induce  AMP-appropriate  re-
sponses.  Higher  doses  of nimodipine  combined with  AMP
did  not  increase  the  magnitude  of  this  effect.  Nimodipine
enhanced  the effects of AMP  on  response rate. Haloperidol
(0.125 mg/kg)  increased  by  approximately  4-fold,  whereas
diazepam  (0.5  or  1.0 mg/kg)  and  morphine  (5.0 mg/kg)  in-
creased  by  approximately  2-fold  the  AMP  dose  necessary
to induce AMP-appropriate  responses. The interaction with
AMP  was  associated with  enhanced  reduction  of response
rate  in  the  tests with  diazepam and morphine  but  not  halo-
peridol.  These  results  suggest  that  nimodipine  attenuates
the DS  properties of AMP,  probably in  a  non-specific way,
due  to  the  ability of nimodipine  itself to  induce  a  discrimin-
able  internal  state.

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