| ²é¿´: 1305 | »Ø¸´: 3 | ||
bartob123321ͳæ (СÓÐÃûÆø)
|
[ÇóÖú]
ÇóÖúһС¶ÎÎÄÏ׵ķÒë ÒÑÓÐ1È˲ÎÓë
|
| Breast cancer (BC) is the most common malignant tumor in women, obesity is associated with increased BC incidence and mortality and high levels of circulating insulin may negatively impact on cancer incidence. In the present study, we investigated whether the strength of several anthropometric and metabolic parameters varies between BCmolecular subtypes. Eligible cases were 991 non-metastatic BC patients recruited between January 2009 and December 2013. Anthropometric, clinical and immunohistochemical features were measured. Multivariate logistic regression models were built to assess HER2 positive BC risk, comparing (a) triple positive (TP) with luminal A, luminal B and triple negative (TN) and (b) HER2-enriched group with luminal A, luminal B and TN. luminal A in relation to age. Among postmenopausal patients, the adjusted multivariate analysis showed that high BMI and high waist circumference were inversely correlated to TP subtype when compared to luminal B (OR = 0.48 and OR = 0.49, respectively). Conversely, HOMA-IR was a risk factor for TP when compared to luminal A and TN (OR = 2.47 and OR = 3.15, respectively). Our findings suggest a potential role of higher abdominal fat in the development of specific BC molecular subtypes in postmenopausal women. Moreover, they support a potential role of insulin resistance in the development of HER2 positive BC, although this role appears to be stronger when hormone receptors are co-expressed, suggesting a difference in the etiology of these two BC subtypes. |
» ²ÂÄãϲ»¶
Ò»Ö¾Ô¸»ª¶«Ê¦·¶ÉúÎïѧ326·Ö£¬Çóµ÷¼Á
ÒѾÓÐ4È˻ظ´
071000ÉúÎïѧµ÷¼ÁÇóÖú
ÒѾÓÐ11È˻ظ´
»¯Ñ§¹¤³ÌÓë¼¼Êõ324µ÷¼Á
ÒѾÓÐ16È˻ظ´
298Çóµ÷¼Á
ÒѾÓÐ4È˻ظ´
282£¬Çóµ÷¼Á
ÒѾÓÐ9È˻ظ´
¿¼Ñе÷¼Á
ÒѾÓÐ19È˻ظ´
308Çóµ÷¼Á
ÒѾÓÐ20È˻ظ´
ÖпÆÔº×Ü·Ö315Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
Çóµ÷¼Á ²ÄÁÏÓ빤³Ì 324·Ö ר˶
ÒѾÓÐ3È˻ظ´
Ò»Ö¾Ô¸¿ó´ó£¬²ÄÁϹ¤³Ìר˶314·Ö£¬0856¿Éµ÷¶¼¿ÉÒÔ
ÒѾÓÐ12È˻ظ´
» ±¾Ö÷ÌâÏà¹Ø¼ÛÖµÌùÍÆ¼ö£¬¶ÔÄúͬÑùÓаïÖú:
ÇóÖú·ÒëһС¶ÎÓ¢ÎÄÎÄÏס£
ÒѾÓÐ1È˻ظ´
[ÇóÖú]һС¶ÎµÂÓïµÄÎÄÏ×£¬¸½¼þÓÐÔÎÄͼƬ¡£»¹Çë´ïÈ˰ïæ·Ò룬лл£¡
ÒѾÓÐ3È˻ظ´
Óп´µÃ¶®µÂÎÄÎÄÏ׵ĴóÉñÂ𣿰ïæ·ÒëһС¶Îѽ
ÒѾÓÐ7È˻ظ´
ÇóÖú·ÒëһƪµÂÓïÎÄÏ×µÄһС¶Î£¨ÊµÑé²½Ö貿·Ö£©
ÒѾÓÐ1È˻ظ´
·ÒëÇóÖú£¬ÏÂÃæÒ»¶Î¾ä×Ó·Òë³ÉÓ¢ÎÄ
ÒѾÓÐ0È˻ظ´
[font=ºÚÌå]µÂÓïÇóÖú[/font]
ÒѾÓÐ1È˻ظ´
ÇóÖú·ÒëһС¶ÎÈÕÎÄ »¯Ñ§ºÏ³É·½Ãæ
ÒѾÓÐ2È˻ظ´
ÇóÖúС¶ÎÕªÒª·Òë
ÒѾÓÐ1È˻ظ´
ÇóÖú¸ßÊÖ°ïæ·ÒëһС¶ÎÓ¢ÎÄ£¡£¡£¡
ÒѾÓÐ1È˻ظ´
ÇóÖú·ÒëһС¶ÎÓ¢ÎÄÎÄÏ×£¬100´Ê×óÓÒ£¬¹ØÓÚË«Ïà¸Ö¿×¶´²úÉúµÄ
ÒѾÓÐ1È˻ظ´
ÇóÖú·ÒëÒ»¶Î»°£¬ÖÐÒëÓ¢£¬²»ÒªÖ±½Ógoogle·ÒëàÞ
ÒѾÓÐ4È˻ظ´
ÇóÖú·ÒëһС¶Î·Ö×Ó·½ÃæµÄÎÄÏ×
ÒѾÓÐ1È˻ظ´
ÇóÖú·ÒëµÂÓïһС¶Î
ÒѾÓÐ1È˻ظ´
Å·ÖÞÎÞ»ú»¯Ñ§ÎÄÏ×ÖеÄһС¶Î·Òë
ÒѾÓÐ1È˻ظ´
¡¾ÇóÖú¡¿Çó·Òë¾ÛºÏÎïÊõÓï
ÒѾÓÐ4È˻ظ´
´ß»¯°æÉÏ2008-04-25ǰ ·Ðʯ·Ö×Óɸ£¬ZSM-ϵ¡¢SAPO-ϵ ¹²466¸ö»°Ì⼯½õ
ÒѾÓÐ110È˻ظ´

¡¢»ð»ð
гæ (³õÈëÎÄ̳)
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 94.2
- Ìû×Ó: 42
- ÔÚÏß: 17Сʱ
- ³æºÅ: 5135261
- ×¢²á: 2016-10-18
- רҵ: ¸ß·Ö×Ó²ÄÁϽṹÓëÐÔÄÜ
|
Ìṩ¸÷ÖÖÖÐÓ¢·Òë·þÎñ£¬×¨ÒµÍŶӣ¬ÖÊÁ¿ÓÅ£¬¼Û¸ñʵ»Ý¡£»¶Ó×Éѯ¡£ ·¢×ÔСľ³æAndroid¿Í»§¶Ë |
2Â¥2016-10-23 21:53:25
jiangguofeng
½ð³æ (ÖøÃûдÊÖ)
- Ó¦Öú: 41 (СѧÉú)
- ½ð±Ò: 25968.4
- ºì»¨: 25
- Ìû×Ó: 2116
- ÔÚÏß: 567.1Сʱ
- ³æºÅ: 72410
- ×¢²á: 2005-06-04
- רҵ: ºÏ³ÉÒ©Îﻯѧ
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
bartob123321(¿Õλ´ú·¢): ½ð±Ò+45, ¸ÐлӦÖú 2017-01-19 22:07:11
¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
bartob123321(¿Õλ´ú·¢): ½ð±Ò+45, ¸ÐлӦÖú 2017-01-19 22:07:11
|
½÷¹©²Î¿¼£º ÈéÏÙ°©£¨BC£©ÊÇÅ®ÐÔ×î³£¼ûµÄ¶ñÐÔÖ×Áö,·ÊÅÖÖ¢ÓëBCµÄ·¢ÉúÂʺÍËÀÍöÂÊÏà¹Ø²¢ÇÒѪÇåÖиßŨ¶ÈµÄÒȵºËØ¿ÉÄܶ԰©Ö¢·¢ÉúÂʲúÉú¸ºÃæÓ°Ïì¡£ÔÚ±¾Ñо¿µ±ÖÐ,ÎÒÃǵ÷²éÁ˼¸¸öÈËÌå²âÁ¿ºÍг´úлŨ¶È²ÎÊýÊÇ·ñ»áÔÚBC·Ö×ÓÑÇÐÍÖ®¼ä·¢Éú±ä»¯¡£·ûºÏÌõ¼þµÄ²¡ÀýÊÇÓÚ2009ÄêÒ»ÔºÍ2013ÄêÊ®¶þÔ¿µ¸´µÄ991Àý·Ç×ªÒÆÐÔµÄBC»¼Õß¡£ ¼ì²âÁËÈËÌå²âÁ¿µÄ¡¢ÁÙ´²µÄºÍÃâÒß×éÖ¯»¯Ñ§µÄÌØÕ÷¡£½¨Á¢Á˶à±äÁ¿Âß¼»Ø¹éÄ£ÐÍÒÔÆÀ¼ÛHER2ÑôÐÔBC·çÏÕ,(a)ÈýÑôÐÔ(TP)Óë¹ÜÇ»A¡¢¹ÜÇ»B½øÐбȽϣ¬ÈýÒõÐÔ(TN)ºÍ(b) HER2-Ç¿»¯×éÓë¹ÜÇ»A¡¢¹ÜÇ»BºÍÓëÄêÁäÓйصÄTN¹ÜÇ»A½øÐбȽϡ£ÔÚ¾¾øºóµÄ»¼Õßµ±ÖÐ,¾µ÷ÕûµÄ¶à±äÁ¿·ÖÎöÏÔʾÓë¹ÜÇ»B£¨·Ö±ðOR=0.48£¬OR=0.49£©Ïà±Èʱ¸ßBMIºÍ¸ßÑüΧÓëTPÑÇÐͳʸºÏà¹Ø¡£Ïà·´,µ±Óë¹ÜÇ»AºÍTN(·Ö±ðOR=2.47£¬OR=3.15£©Ïà±ÈʱÒȵºËصֿ¹Ö¸Êý¶ÔÓÚTPÊÇÒ»¸öΣÏÕÒòËØ¡£ÎÒÃǵÄÑо¿½á¹ûÏÔʾ³ö¸ß¸¹²¿Ö¬·¾ÔÚ¾ø¾ºó¸¾Å®Ìض¨BC·Ö×ÓÑÇÐÍ·¢Õ¹¹ý³ÌÖеÄDZÔÚ×÷ÓᣴËÍâ,ÕâЩ»¹×ôÖ¤ÁËÒȵºËصֿ¹ÔÚHER2ÑôÐÔBC·¢Õ¹¹ý³ÌÖеÄDZÔÚ×÷ÓÃ,¾¡¹ÜÕâÖÖ×÷ÓÃÔÚ¼¤ËØÊÜÌå¹²±í´ïÊ±ËÆºõ¸üÇ¿,ÏÔʾ³öÕâÁ½¸öBCÑÇÐÍÔÚ²¡ÔѧÖеIJîÒì¡£ |
3Â¥2016-10-24 11:23:31
4Â¥2016-10-26 10:13:56













»Ø¸´´ËÂ¥
