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929323

铜虫 (小有名气)

[求助] 江湖救急,实在不知道该怎么回答审稿人的问题了啊!求大神帮忙! 已有3人参与

小弟最近收到了杂志的审稿意见,1号审稿人同意发表。2号审稿人体的问题着实不知道该怎么回答,还请各位虫友帮帮忙啊!!!!!江湖救急!
意见如下:
In figure 5 and 6 authors showed that there is increase in mRNA and protein expression of I<kappa>B<alpha> after Con-A injection which is reversed by 某治疗药物. But as a matter of fact I<kappa>B<alpha> gets ubiquitinated and phosphorylated by IKK<beta> and subsequently degraded before the activation of NF-<kappa>B to induce cytokine production. But, here this is not the fact and on the contrary, in this study after 某治疗药物 treatment, there is a reduction in I<kappa>B<alpha> and also NF-<kappa>B expression which is going against the hypothesis of the manuscript and the classical pathway. I would suggest the authors to clarify the issue.
到底该怎么回复呢。。。。。。
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自私的猫1988

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【答案】应助回帖

感谢参与,应助指数 +1
审稿人意思是你的文章数据显示和得到结论、传统情况相背离,让你解释一下
there is a reduction in I<kappa>B<alpha> and also NF-<kappa>B expression which is going against the hypothesis of the manuscript and the classical pathway
2楼2015-04-01 19:03:01
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929323

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引用回帖:
2楼: Originally posted by 自私的猫1988 at 2015-04-01 19:03:01
审稿人意思是你的文章数据显示和得到结论、传统情况相背离,让你解释一下
there is a reduction in I<kappa>B<alpha> and also NF-<kappa>B expression which is going against the hypothesis  ...

我知道啊 但是我在想怎么回答,因为IKB和NFKB同时身高,我觉得可能是我选择的作用时间点的原因。
3楼2015-04-01 19:27:31
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自私的猫1988

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引用回帖:
3楼: Originally posted by 929323 at 2015-04-01 19:27:31
我知道啊 但是我在想怎么回答,因为IKB和NFKB同时身高,我觉得可能是我选择的作用时间点的原因。...

这个专业问题学过生物的我半斤八两,请教一下周围比较专业的吧
或者在生物科学或分子生物版块问问
4楼2015-04-01 19:32:44
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jchen2014

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【答案】应助回帖

感谢参与,应助指数 +1
同意一楼的看法,建议在网上搜索相关文献去佐证你的观点。或者你的结论是否需要在修改一下
5楼2015-04-01 22:50:05
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格子和潇潇

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【答案】应助回帖

感谢参与,应助指数 +1
如果是浓度梯度,可能药物浓度没有到达 IkB下降的点;或者你需要找到另外的刺激NFkB表达的另外通路,讨论里推测在你这个组织或细胞可能是另外的通路在起作用;你的文章导师没有看过么?怎么这么明显的问题不在讨论里做解释呢?

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6楼2015-04-01 23:15:48
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