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figure1E:Heatmap depicts genomic intervals (rows) enriched for H3K27ac in tumor models (cyan: high signal), clustered into groups of TPC-specific, DGC-specific, and shared regulatory elements. Shared elements tend to be located proximal to promoters, whereas the vast majority of TPC- and DGC-specific elements are distal. Motif analyses predict binding sites for TF families within each set of elements.
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figure2C:(C) ChIP-seq tracks show H3K27ac signals for loci encoding TPC-specific TFs OLIG1, OLIG2, and SOX2. 其中TPC和DGC是两种不同处理方法下的同种细胞,MGG4\6\8是来源不同的GBM细胞。 |