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柒捌玖

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[求助] 求翻译一份论文摘要,急求 已有1人参与

本文主要介绍了3-溴丁酸甲酯的合成工艺。3-溴丁酸甲酯作为重要的医药中间体,市场需求越来越大,国内外对3-溴丁酸合成工艺的研究也越来越多。我们从多条合成工艺中选择成本最低的一条的合成工艺来实现3-溴丁酸甲酯的工业化。首先以价格便宜的巴豆酸为原料,在70-80 ℃之间合成巴豆酸甲酯,在巴豆酸甲酯合成过程中尝试了不同催化剂对对巴豆酸甲酯的合成收率的影响,得出浓硫酸的催化效果最好,巴豆酸甲酯的收率可达到95%。由第一步合成的巴豆酸甲酯乙酸做溶剂与溴化氢加成合成3-溴丁酸甲酯,探究不同反应条件下3-溴丁酸甲酯的收率,得出当实验温度为10℃,物料比(溴化氢:巴豆酸甲酯)为1.8:1的条件下3-溴丁酸甲酯的收率最高,可达90%。
关键词:巴豆酸 巴豆酸甲酯 3-溴丁酸甲酯
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feiwn

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This article mainly introduced the synthetic process of 3 - methyl bromide butyric acid.3 - methyl bromide butyric acid as an important pharmaceutical intermediates, market demand is more and more big, at home and abroad for 3 - bromine butyric acid synthesis technology research also more and more.We choose the lowest cost from multiple synthesis process of a synthetic process to realize the industrialization of 3 - methyl bromide butyric acid.Start with cheap crotonic acid as raw materials, synthesis between 70-80 ℃ crotonic acid methyl ester, in the process of crotonic acid methyl ester synthesis tried different catalysts on the yield of crotonic acid methyl ester synthesis, draw a sulfuric acid catalytic effect is best, crotonic acid methyl ester yield can reach 95%.By the first step in the synthesis of crotonic acid methyl acetate solvent and additive synthesis of 3 - methyl bromide butyric acid hydrogen bromide, explore different reaction conditions the yield of 3 - methyl bromide butyric acid, it is concluded that when the experiment temperature is 10 ℃, the material ratio (hydrogen bromide: crotonic acid methyl ester) of 1.8:1 under the condition of 3 - methyl bromide butyric acid yield was the highest, up to 90%.
Keywords: crotonic acid, crotonic acid methyl 3 - methyl bromide butyric acid
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