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The manuscript has been reviewed by three experts. Their recommendations are highly divergent. Reviewers #1 recommends rejection of the manuscript. Reviewers #3 is also highly critical, but this reviewer recommends that the manuscript may possibly be considered for publication after a major revision. In contrast, Reviewers #2 is positive. This reviewer recommends acceptance of the manuscript. The comments of Reviewers #1 and - to a lesser extent - Reviewers #3 seem to disqualify the manuscript. However, because of the positive comments of the latter two reviewers, the authors deserve a chance to respond and to improve their manuscript in line with the recommendations of the reviewers. The authors should carefully address all issues raised by the reviewers and they should improve the manuscript in line with the recommendations of the reviewers. If necessary, they should perform additional experiments. ÎÄÕÂÒÑ¾ÖØÍ¶¹ýÁË£¬ÓÐÒ»¸öÉó¸åÈË´ÓʼÖÁÖÕ·ñ¶¨£¬¸Ð¾õÒ»µã¿´²»µ½ÎÄÕµÄÓŵ㣬ËùÓеͼÊÇȱµã£¬ÎÒ¾õµÃÊdz£Ê¶µÄ¶«Î÷Ëû¾õµÃ¶¼ÊÇ´íµÄ£¬ÎÒ¾õµÃ×Ô¼ºÊÇÎÞ·¨Ëµ·þËûÁË£¬×¼±¸È«²¿ÒÔ·´²µµÄÐÎʽ»Ø¸´ÁË£¬Â¼²»Â¼È¡²»¹ÜÁË£¬Ì«ÀÛÁË¡£ÏÖÔÚ¾À½áµÄʱҪ²»ÒªºÍ±à¼ËµËµÎÞ·¨°´ÕÕÕâ¸öÉó¸åÈ˵ÄÒâ¼ûÐ޸ģ¬±à¼¼ÈÈ»²»¹ËËûµÄ·´¶ÔÈÃÎÒÐ޸Ϲ»áÔÙ¸øËûÉóÂð£¿ÎÒ¹À¼Æ±à¼¸øÎÒ´óÐÞÊÇÒòΪÀ´»ØÕÛÌÚÎÒ°ëÄêÁË£¬ÎÒ±¾À´ÐµĶ«Î÷¶¼³ÉÁ˾ɵÄÁË¡£Óöµ½¹ÌÖ´ÓÖÓÐÆ«¼ûµÄÉó¸åÈËÕæÊÇÉ˲»Æð¡£ |
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