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qq522384905银虫 (初入文坛)
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[求助]
请大家帮我翻译下下面这段话呀？谢谢！
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| This 'proof of concept' study was implemented in anticipation of identifying and testing a novel antigen of human origin as a potential immunogen in a paradigm that emphasizes immunomodulation and immune system reconstitution as requisites to the development of an effective human immunodeficiency virus (HIV)-acquired immune deficiency syndrome vaccine. Fifteen HIV-infected, highly active antiretroviral therapy (HAART) naive, otherwise healthy male seropositive patients were stratified by [CD4+] into 3 groups of 5 patients: group 1 >500/mm; group 2 > 250/mm but <500/mm; and group 3 < 250/mm. Five healthy male subjects were used as controls. Replicate peripheral blood mononuclear cell (PBMC) [H]thymidine uptake phytohemaglutinin-stimulated proliferation studies, and serum cytokine assays were carried out in the presence or absence of Kveim antigen at dilutions ranging from 0.001 to 100 mug/mL. Serum cytokines [interleukin-2 (IL-2), IL-4, IL-6, interferon gamma, and tumor necrosis factor alpha] were assayed using standardized methodology. Nonparametric statistical analyses and linear regression analysis were used to test for statistical significance and strength of associations. PBMCs harvested from HIV-infected patients and incubated, ex vivo, demonstrated reproducible, antigen concentration-dependent changes in cytokine production over a range of antigen concentrations (0.001-100 mug/mL) in contrast to antigen-naive PBMCs and controls. Significant correlations were demonstrated between antigen concentration and the amount of cytokines secreted. The magnitude of the cytokine response and the patterns of cytokine secretion were HIV group-specific and could be used to identify and distinguish between the 3 groups of HIV-infected subjects. A shift toward the production of type 1-like (Th1) cytokines characteristically seen in systemic sarcoidosis and associated with effective HAART was seen when patterns of cytokine secretion were compared between antigen exposed and antigen-naive PBMCs. PBMCs harvested from seropositive HIV-infected patients and exposed to the Kveim antigen have the following properties: (1) They demonstrate proliferation and exhibit an antigen concentration-dependent secretion of cytokines. The magnitude of the cytokine response can be used to identify and distinguish between groups of seropositive patients stratified by [CD4+]. (2) These PBMCs secrete cytokines in patterns suggestive of a shift to a type 1-like (Th1) response characteristic of HAART and sarcoidosis as opposed to the type 2-like (Th2) cytokine profile characteristic of HIV-acquired immune deficiency syndrome. |
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wujianchana
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2楼2012-10-16 08:30:26
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3楼2012-10-16 08:46:01
dengxuan1993
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qq522384905: 金币+4, ★有帮助 2012-10-16 12:00:08
qq522384905: 金币+4, ★有帮助 2012-10-16 12:00:08
这种“概念验证”研究是实现预期的确定和测试一个新颖的抗原起源于人类作为一个潜在的免疫原在范式强调免疫调节和免疫系统重构作为前提到开发有效的人类免疫缺陷病毒(HIV)获得性免疫缺陷综合征疫苗。15艾滋病毒感染,高活性抗逆转录病毒疗法(HAART)天真,否则健康男性血清反应阳性的患者被分成了[CD4 +]到3组5例:第1组> 500 / mm;第二组> 250 / mm但< 500 / mm;和组3 < 250 / mm。五个健康的男性受试者被用作控制。复制外周血单核细胞(PBMC)[H]胸苷吸收phytohemaglutinin-stimulated扩散研究,和血清细胞因子进行了分析的存在或缺少Kveim抗原在稀释从0.001到100杯/毫升。血清细胞因子[药物(il 2),il 4,il - 6,干扰素伽马,肿瘤坏死因子-α]使用标准化的方法定位试验地。非参数统计分析和线性回归分析是用来测试统计意义和强度的关联。PBMCs是从hiv感染者和孵化,体外,演示了可再生的,抗原浓度相关的细胞因子的变化范围内,生产抗原浓度(0.001 -100杯/毫升)与抗原天真的PBMCs和控制。显著的相关性之间也证明了抗原浓度和细胞因子分泌量。细胞因子的幅度响应和模式的细胞因子分泌被艾滋病毒组特有的和可以用来识别和区分3组感染艾滋病毒的科目。转向生产类型1像(Th1)细胞因子典型出现在系统性结节病和相关有效HAART被认为当模式的细胞因子分泌比较抗原暴露和抗原天真的PBMCs。PBMCs是从血清反应阳性的艾滋病病毒感染者和暴露在Kveim抗原具有以下属性 1)他们演示核扩散和展览抗原分泌的细胞因子浓度的依赖。细胞因子的幅度响应可以用来识别和区分组血清反应阳性的病人分成了[CD4 +]。(2)这些PBMCs分泌细胞因子在模式使联想转向一个类型1像(Th1)响应特性的鸡尾酒疗法和结节病而不是类型2像(核)细胞因子剖面特征的艾滋病毒获得免疫缺陷综合症。 |
4楼2012-10-16 08:59:57