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zxm1985金虫 (正式写手)
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[求助]
求高手帮忙翻译一段文字，药代动力学方面的，急，急，急。
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Absorption Peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg BID; at higher doses there are less than proportional increases in Cmax and AUC (see Food Effects). Absolute bioavailability studies have not been conducted. With multiple dosing, steady state conditions are reached on or before day 5. Food Effects When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Under fasting conditions, at doses above 200 mg, there is less than a proportional increase in Cmax and AUC, which is thought to be due to the low solubility of the drug in aqueous media. Coadministration of CELEBREX with an aluminum- and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in AUC.  |
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iamzane
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zxm1985: 金币+15, ★★★★★最佳答案 2012-08-10 15:14:06
感谢参与，应助指数 +1
zxm1985: 金币+15, ★★★★★最佳答案 2012-08-10 15:14:06
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Absorption Peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg BID; at higher doses there are less than proportional increases in Cmax and AUC (see Food Effects). Absolute bioavailability studies have not been conducted. With multiple dosing, steady state conditions are reached on or before day 5. 吸收 口服三小时后塞来昔布达到血浆峰值。空腹状态下，血浆峰值（Cmax）和曲线下面积（AUC）在200mg BID下剂量成比例；更高剂量下，Cmax和AUC增长低于比例（见食物作用）。未作绝对生物利用度研究。 多次给药，在第五天达到稳态条件，或更早。 Food Effects When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Under fasting conditions, at doses above 200 mg, there is less than a proportional increase in Cmax and AUC, which is thought to be due to the low solubility of the drug in aqueous media. Coadministration of CELEBREX with an aluminum- and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in AUC. 食物作用 塞来昔布随高脂肪食物同服，血浆峰值延迟1-2小时，同时总体吸收（AUC）上升10-20%。空腹状态下，200mg以上剂量，Cmax和AUC增长低于比例，这是由于药物在水介质中溶解性较低。塞来昔布与含铝或含镁抗酸药物合用导致塞来昔布血浆浓度下降，Cmax和AUC分别下降37%和10%。 |
zxm19852楼2012-08-10 09:05:07
zxm1985
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3楼2012-08-10 13:48:34
cmwuyan
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4楼2012-08-10 14:21:04
zxm1985
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5楼2012-08-10 14:52:35
