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the authors claim that energy for interaction energy between tyrosine and dG (nucleotide) increased from 6.2 kcal/mol to 12.5 kcal/mol after equilibrium and dynamic simulation. This corresponds to a deltadelta G of are greater than 6 kcal/mol, a value that is far too high for simple H-bonds or even a single electrostatic interaction. I do not believe this number has any real meaning. The authors must explain this in better detail. How is this caused by "enhanced electrostatic energy"?

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zh1987hs: ½ð±Ò+3, лл 2012-04-01 17:18:06
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The interaction energy between tyrosine and nucleotide was not constant and there existed a variation. For example, At the beginning of the MD simulation, the interaction energy fluctuated from 6 kcal/mol to 7.3 kcal/mol; at the end of MD, this interaction energy fluctuated from 11.3 kcal/mol to 12.5 kcal/mol. To emphasize the increase of the interaction energy during the MD process, we chose 6.2 kcal/mol and 12.5 kcal/mol at the beginning/end of MD, but the actual change of the interaction energy should be less obvious. In the present manuscript, we added the standard deviation when the interaction energy was analyzed.
Furthermore, it has been reported that the hydrogen bond energy is about 23.3 kj/mol (5.6 kcal/mol)£¬ Therefore, basically the H-bond energy between tyrosine and nucleotide is reasonable.
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4Â¥2012-03-31 12:43:33
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zh1987hs: ½ð±Ò+2, лл 2012-04-01 17:18:59
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4Â¥: Originally posted by tuwenwuguan at 2012-03-31 12:43:33:
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The interaction energy between tyrosine and nucleotide was not constant and there existed a variation. For example, At the beginning of the MD simulation,  ...

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3Â¥: Originally posted by itsok at 2012-03-30 18:21:36:
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We analyzed the VDW Interaction Energy and Electrostatic Interaction Energy which constituted the interaction energy between Ser94 and dG, and we found the interaction energy was changed due to the increase of Electrostatic Interaction Energy, the VDW Interaction Energy varied little.
7Â¥2012-04-01 14:57:22
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