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xiangf

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[求助] Nexplanon的专利帮忙找找~~~~~~~~~~

Merck公司近日表示在美国上市68mg的Nexplanon (etonogestrel、依托孕烯) 皮下植入棒式避孕药。

这个避孕药的专利找不到，请高手们帮帮忙！！

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1楼2011-12-23 15:51:19

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hnsqwxp

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【答案】应助回帖

★ ★
豆哥(金币+2): 感谢参与交流 2011-12-24 09:24:38

Intrauterine system for retaining and releasing therapeutically effective dose of e.g. biologically active compound within uterus of human for treatment of e.g. menorraghia, has retention elements retaining frame within uterus of mammal
专利号: US2010280464-A1 ; WO2010128004-A1
发明人: DE GRAAFF W, VEENSTRA H, MARTINE T M T, MULDERS T M T
专利权人和代码:ORGANON NV(ORGA-C)
Derwent 主入藏号: 2010-N76468 [79]
被审查员引用的专利: 6
摘要: NOVELTY - The system (200) has a deposit i.e. rod-shaped deposit, of a therapeutically effective dose of a biologically active compound. A frame defines an interior space for receipt of the deposit, where the frame has an open structure allowing access to a part of an outer surface of the deposit. Multiple retention elements retain the frame within a uterus of a female mammal. The frame interacts with the deposit to form a mechanical structure having a bending stiffness greater than the sum of that of the frame and deposit taken individually.

USE - Intrauterine system for retaining and releasing a therapeutically effective dose of a biologically active compound within uterus of female mammal i.e. human, for treatment of a medical condition e.g. dysfunctional uterine bleeding, menorraghia, dysmenorrhoea, endometriosis, uterine fibroids, climacteric complaints, osteoporosis and urogenital atrophy (all claimed). Uses include but are not limited to nomegestrol acetate (NOMAc), natural progesterone, levonogestrel, etonogestrel, dydrogesterone, medrogestone, medroxyprogesterone acetate, megestrol acetate, chlormadinone acetate and cyproterone acetate.

ADVANTAGE - The part of the outer surface of the deposit is directly exposed to an environment due to the open structure of the frame, so that the rate controlling effect on a steady state release of the compound to the uterus can be primarily determined by the structure of the deposit and the environment in which the structure is placed, thus enabling relatively easy prediction of release rates within the frame. The flexible frame and the deposit interact to form a composite mechanical structure, so that the system has greater mechanical strength such as bending stiffness, thus achieving an improved structure that ensures adequate strength while ensuring ease of insertion due to the small cross-section of the frame.

详细说明 - INDEPENDENT CLAIMS are also included for the following:

(1) a method for manufacturing an intrauterine system

(2) a method for treating a female mammal.

附图说明 - The drawing shows a perspective view of an intrauterine system prior to assembly.

Intrauterine system (200)

Stem (204)

Frame halves (205, 205')

Living hinges (207, 207')

Snap elements (209)

显示文献摘要
附图:

国际专利分类: A61M-037/00; B23P-011/00; A61F-006/00; A61F-006/14; A61K-009/00
德温特分类代码: A96 (Medical, dental, veterinary, cosmetic); B07 (General - tablets, dispensers, catheters); B01 (Steroids including systems with rings fused to basic steroid structure); P34 (Sterilising, syringes, electrotherapy); P56 (Machine tools)
德温特手工代码: A11-B07; A12-V03D; B01-C03; B01-C04; B01-C05; B11-C03; B11-C04; B12-M10; B12-M12L; B14-D01B; B14-D01C; B14-F08; B14-H05; B14-N01A; B14-N07; B14-N14; B14-S18
专利详细信息:
专利号公开日期主 IPC 周页数语种
US2010280464-A1 04 Nov 2010 A61M-037/00 201079 Pages: 11 English
WO2010128004-A1 11 Nov 2010 A61F-006/14 201079      English
申请详细信息:
US2010280464-A1 US770105 29 Apr 2010
WO2010128004-A1 WOEP055948 03 May 2010
优先权申请信息和日期:
EP159353 04 May 2009
指定国家 (地区)/区域:
WO2010128004-A1:
   国家 (地区): AE; AG; AL; AM; AO; AT; AU; AZ; BA; BB; BG; BH; BR; BW; BY; BZ; CA; CH; CL; CN; CO; CR; CU; CZ; DE; DK; DM; DO; DZ; EC; EE; EG; ES; FI; GB; GD; GE; GH; GM; GT; HN; HR; HU; ID; IL; IN; IS; JP; KE; KG; KM; KN; KP; KR; KZ; LA; LC; LK; LR; LS; LT; LU; LY; MA; MD; ME; MG; MK; MN; MW; MX; MY; MZ; NA; NG; NI; NO; NZ; OM; PE; PG; PH; PL; PT; RO; RS; RU; SC; SD; SE; SG; SK; SL; SM; ST; SV; SY; TH; TJ; TM; TN; TR; TT; TZ; UA; UG; US; UZ; VC; VN; ZA; ZM; ZW
化合物
DCR 号特征描述 DCR 号特征描述 DCR 号特征描述
102210-1-0-0 (K M) 6478-1-0-0 (K M) 94705-1-0-0 (K M)
13759-2-0-0 (K M) 100334-1-0-0 (K M) 100338-1-0-0 (K M)
100358-1-0-0 (K M) 90738-1-0-0 (K M) 166768-1-0-0 (K M)
102310-2-0-0 (K M)
环系索引号:
10975
Derwent 化合物号:
化合物号特征描述化合物号特征描述化合物号特征描述
R19407 (K M) R00145 (K M) RA2UMU (K M)
R15326 (K M) RA24UQ (K M) R00308 (K M)
R12004 (K M) R01209 (K M) R01250 (K M)
R04886 (K M) R13690 (K M)
Derwent 注册号:
注册号特征描述注册号特征描述注册号特征描述
0145 (S) 0308 (S) 1209 (S)
1250 (S)

这个是DII查到的信息，，wo专利里指定了CN的哦。