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¶¹¸ç(½ð±Ò+2): ¸Ðл²ÎÓë½»Á÷ 2011-12-24 09:24:38
¶¹¸ç(½ð±Ò+2): ¸Ðл²ÎÓë½»Á÷ 2011-12-24 09:24:38
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Intrauterine system for retaining and releasing therapeutically effective dose of e.g. biologically active compound within uterus of human for treatment of e.g. menorraghia, has retention elements retaining frame within uterus of mammal רÀûºÅ: US2010280464-A1 ; WO2010128004-A1 ·¢Ã÷ÈË: DE GRAAFF W, VEENSTRA H, MARTINE T M T, MULDERS T M T רÀûȨÈ˺ʹúÂë:ORGANON NV(ORGA-C) Derwent Ö÷Èë²ØºÅ: 2010-N76468 [79] ±»Éó²éÔ±ÒýÓõÄרÀû: 6 ÕªÒª: NOVELTY - The system (200) has a deposit i.e. rod-shaped deposit, of a therapeutically effective dose of a biologically active compound. A frame defines an interior space for receipt of the deposit, where the frame has an open structure allowing access to a part of an outer surface of the deposit. Multiple retention elements retain the frame within a uterus of a female mammal. The frame interacts with the deposit to form a mechanical structure having a bending stiffness greater than the sum of that of the frame and deposit taken individually. USE - Intrauterine system for retaining and releasing a therapeutically effective dose of a biologically active compound within uterus of female mammal i.e. human, for treatment of a medical condition e.g. dysfunctional uterine bleeding, menorraghia, dysmenorrhoea, endometriosis, uterine fibroids, climacteric complaints, osteoporosis and urogenital atrophy (all claimed). Uses include but are not limited to nomegestrol acetate (NOMAc), natural progesterone, levonogestrel, etonogestrel, dydrogesterone, medrogestone, medroxyprogesterone acetate, megestrol acetate, chlormadinone acetate and cyproterone acetate. ADVANTAGE - The part of the outer surface of the deposit is directly exposed to an environment due to the open structure of the frame, so that the rate controlling effect on a steady state release of the compound to the uterus can be primarily determined by the structure of the deposit and the environment in which the structure is placed, thus enabling relatively easy prediction of release rates within the frame. The flexible frame and the deposit interact to form a composite mechanical structure, so that the system has greater mechanical strength such as bending stiffness, thus achieving an improved structure that ensures adequate strength while ensuring ease of insertion due to the small cross-section of the frame. Ïêϸ˵Ã÷ - INDEPENDENT CLAIMS are also included for the following: (1) a method for manufacturing an intrauterine system (2) a method for treating a female mammal. ¸½Í¼ËµÃ÷ - The drawing shows a perspective view of an intrauterine system prior to assembly. Intrauterine system (200) Stem (204) Frame halves (205, 205') Living hinges (207, 207') Snap elements (209) ÏÔʾÎÄÏ×ÕªÒª ¸½Í¼: ¹ú¼ÊרÀû·ÖÀà: A61M-037/00; B23P-011/00; A61F-006/00; A61F-006/14; A61K-009/00 µÂÎÂÌØ·ÖÀà´úÂë: A96 (Medical, dental, veterinary, cosmetic); B07 (General - tablets, dispensers, catheters); B01 (Steroids including systems with rings fused to basic steroid structure); P34 (Sterilising, syringes, electrotherapy); P56 (Machine tools) µÂÎÂÌØÊÖ¹¤´úÂë: A11-B07; A12-V03D; B01-C03; B01-C04; B01-C05; B11-C03; B11-C04; B12-M10; B12-M12L; B14-D01B; B14-D01C; B14-F08; B14-H05; B14-N01A; B14-N07; B14-N14; B14-S18 רÀûÏêϸÐÅÏ¢: רÀûºÅ ¹«¿ªÈÕÆÚ Ö÷ IPC ÖÜ Ò³Êý ÓïÖÖ US2010280464-A1 04 Nov 2010 A61M-037/00 201079 Pages: 11 English WO2010128004-A1 11 Nov 2010 A61F-006/14 201079 English ÉêÇëÏêϸÐÅÏ¢: US2010280464-A1 US770105 29 Apr 2010 WO2010128004-A1 WOEP055948 03 May 2010 ÓÅÏÈȨÉêÇëÐÅÏ¢ºÍÈÕÆÚ: EP159353 04 May 2009 Ö¸¶¨¹ú¼Ò (µØÇø)/ÇøÓò: WO2010128004-A1: ¹ú¼Ò (µØÇø): AE; AG; AL; AM; AO; AT; AU; AZ; BA; BB; BG; BH; BR; BW; BY; BZ; CA; CH; CL; CN; CO; CR; CU; CZ; DE; DK; DM; DO; DZ; EC; EE; EG; ES; FI; GB; GD; GE; GH; GM; GT; HN; HR; HU; ID; IL; IN; IS; JP; KE; KG; KM; KN; KP; KR; KZ; LA; LC; LK; LR; LS; LT; LU; LY; MA; MD; ME; MG; MK; MN; MW; MX; MY; MZ; NA; NG; NI; NO; NZ; OM; PE; PG; PH; PL; PT; RO; RS; RU; SC; SD; SE; SG; SK; SL; SM; ST; SV; SY; TH; TJ; TM; TN; TR; TT; TZ; UA; UG; US; UZ; VC; VN; ZA; ZM; ZW »¯ºÏÎï DCR ºÅ ÌØÕ÷ÃèÊö DCR ºÅ ÌØÕ÷ÃèÊö DCR ºÅ ÌØÕ÷ÃèÊö 102210-1-0-0 (K M) 6478-1-0-0 (K M) 94705-1-0-0 (K M) 13759-2-0-0 (K M) 100334-1-0-0 (K M) 100338-1-0-0 (K M) 100358-1-0-0 (K M) 90738-1-0-0 (K M) 166768-1-0-0 (K M) 102310-2-0-0 (K M) »·ÏµË÷ÒýºÅ: 10975 Derwent »¯ºÏÎïºÅ: »¯ºÏÎïºÅ ÌØÕ÷ÃèÊö »¯ºÏÎïºÅ ÌØÕ÷ÃèÊö »¯ºÏÎïºÅ ÌØÕ÷ÃèÊö R19407 (K M) R00145 (K M) RA2UMU (K M) R15326 (K M) RA24UQ (K M) R00308 (K M) R12004 (K M) R01209 (K M) R01250 (K M) R04886 (K M) R13690 (K M) Derwent ×¢²áºÅ: ×¢²áºÅ ÌØÕ÷ÃèÊö ×¢²áºÅ ÌØÕ÷ÃèÊö ×¢²áºÅ ÌØÕ÷ÃèÊö 0145 (S) 0308 (S) 1209 (S) 1250 (S) Õâ¸öÊÇDII²éµ½µÄÐÅÏ¢£¬£¬woרÀûÀïÖ¸¶¨ÁËCNµÄŶ¡£ |
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