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Intrauterine system for retaining and releasing therapeutically effective dose of e.g. biologically active compound within uterus of human for treatment of e.g. menorraghia, has retention elements retaining frame within uterus of mammal
רÀûºÅ: US2010280464-A1   ; WO2010128004-A1  
·¢Ã÷ÈË:        DE GRAAFF W, VEENSTRA H, MARTINE T M T, MULDERS T M T
רÀûȨÈ˺ʹúÂë:ORGANON NV(ORGA-C)
Derwent Ö÷Èë²ØºÅ: 2010-N76468 [79]
±»Éó²éÔ±ÒýÓõÄרÀû: 6       
ÕªÒª: NOVELTY - The system (200) has a deposit i.e. rod-shaped deposit, of a therapeutically effective dose of a biologically active compound. A frame defines an interior space for receipt of the deposit, where the frame has an open structure allowing access to a part of an outer surface of the deposit. Multiple retention elements retain the frame within a uterus of a female mammal. The frame interacts with the deposit to form a mechanical structure having a bending stiffness greater than the sum of that of the frame and deposit taken individually.

USE - Intrauterine system for retaining and releasing a therapeutically effective dose of a biologically active compound within uterus of female mammal i.e. human, for treatment of a medical condition e.g. dysfunctional uterine bleeding, menorraghia, dysmenorrhoea, endometriosis, uterine fibroids, climacteric complaints, osteoporosis and urogenital atrophy (all claimed). Uses include but are not limited to nomegestrol acetate (NOMAc), natural progesterone, levonogestrel, etonogestrel, dydrogesterone, medrogestone, medroxyprogesterone acetate, megestrol acetate, chlormadinone acetate and cyproterone acetate.

ADVANTAGE - The part of the outer surface of the deposit is directly exposed to an environment due to the open structure of the frame, so that the rate controlling effect on a steady state release of the compound to the uterus can be primarily determined by the structure of the deposit and the environment in which the structure is placed, thus enabling relatively easy prediction of release rates within the frame. The flexible frame and the deposit interact to form a composite mechanical structure, so that the system has greater mechanical strength such as bending stiffness, thus achieving an improved structure that ensures adequate strength while ensuring ease of insertion due to the small cross-section of the frame.

Ïêϸ˵Ã÷ - INDEPENDENT CLAIMS are also included for the following:

(1) a method for manufacturing an intrauterine system

(2) a method for treating a female mammal.

¸½Í¼ËµÃ÷ - The drawing shows a perspective view of an intrauterine system prior to assembly.

Intrauterine system (200)

Stem (204)

Frame halves (205, 205')

Living hinges (207, 207')

Snap elements (209)

ÏÔʾÎÄÏ×ÕªÒª
¸½Í¼:

¹ú¼ÊרÀû·ÖÀà:        A61M-037/00; B23P-011/00; A61F-006/00; A61F-006/14; A61K-009/00
µÂÎÂÌØ·ÖÀà´úÂë:        A96 (Medical, dental, veterinary, cosmetic); B07 (General - tablets, dispensers, catheters); B01 (Steroids including systems with rings fused to basic steroid structure); P34 (Sterilising, syringes, electrotherapy); P56 (Machine tools)
µÂÎÂÌØÊÖ¹¤´úÂë:        A11-B07; A12-V03D; B01-C03; B01-C04; B01-C05; B11-C03; B11-C04; B12-M10; B12-M12L; B14-D01B; B14-D01C; B14-F08; B14-H05; B14-N01A; B14-N07; B14-N14; B14-S18
רÀûÏêϸÐÅÏ¢:
רÀûºÅ        ¹«¿ªÈÕÆÚ        Ö÷ IPC        ÖÜ        Ò³Êý        ÓïÖÖ
US2010280464-A1         04 Nov 2010        A61M-037/00        201079         Pages: 11         English
WO2010128004-A1         11 Nov 2010        A61F-006/14        201079                  English
ÉêÇëÏêϸÐÅÏ¢:
US2010280464-A1         US770105         29 Apr 2010
WO2010128004-A1         WOEP055948         03 May 2010
ÓÅÏÈȨÉêÇëÐÅÏ¢ºÍÈÕÆÚ:
EP159353         04 May 2009
Ö¸¶¨¹ú¼Ò (µØÇø)/ÇøÓò:
WO2010128004-A1:
     ¹ú¼Ò (µØÇø): AE; AG; AL; AM; AO; AT; AU; AZ; BA; BB; BG; BH; BR; BW; BY; BZ; CA; CH; CL; CN; CO; CR; CU; CZ; DE; DK; DM; DO; DZ; EC; EE; EG; ES; FI; GB; GD; GE; GH; GM; GT; HN; HR; HU; ID; IL; IN; IS; JP; KE; KG; KM; KN; KP; KR; KZ; LA; LC; LK; LR; LS; LT; LU; LY; MA; MD; ME; MG; MK; MN; MW; MX; MY; MZ; NA; NG; NI; NO; NZ; OM; PE; PG; PH; PL; PT; RO; RS; RU; SC; SD; SE; SG; SK; SL; SM; ST; SV; SY; TH; TJ; TM; TN; TR; TT; TZ; UA; UG; US; UZ; VC; VN; ZA; ZM; ZW
»¯ºÏÎï
DCR ºÅ        ÌØÕ÷ÃèÊö        DCR ºÅ        ÌØÕ÷ÃèÊö        DCR ºÅ        ÌØÕ÷ÃèÊö
102210-1-0-0        (K M)        6478-1-0-0        (K M)        94705-1-0-0        (K M)
13759-2-0-0        (K M)        100334-1-0-0        (K M)        100338-1-0-0        (K M)
100358-1-0-0        (K M)        90738-1-0-0        (K M)        166768-1-0-0        (K M)
102310-2-0-0        (K M)
»·ÏµË÷ÒýºÅ:
10975
Derwent »¯ºÏÎïºÅ:
»¯ºÏÎïºÅ        ÌØÕ÷ÃèÊö        »¯ºÏÎïºÅ        ÌØÕ÷ÃèÊö        »¯ºÏÎïºÅ        ÌØÕ÷ÃèÊö
R19407        (K M)        R00145        (K M)        RA2UMU        (K M)
R15326        (K M)        RA24UQ        (K M)        R00308        (K M)
R12004        (K M)        R01209        (K M)        R01250        (K M)
R04886        (K M)        R13690        (K M)
Derwent ×¢²áºÅ:
×¢²áºÅ        ÌØÕ÷ÃèÊö        ×¢²áºÅ        ÌØÕ÷ÃèÊö        ×¢²áºÅ        ÌØÕ÷ÃèÊö
0145        (S)        0308        (S)        1209        (S)
1250        (S)

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