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Oncogenes and tumor suppressors¡ªand the mutations that affect them¡ªare different beasts from the point of view of the cancer gene hunter. But from a cancer cell's point of view they are two sides of the same target. To bypass this block and see the effect of homozygous mutations in an adult tissue, one can use the methods to create conditional mutations, such that only one tissue¡ªsay the liver¡ªdisplays the defect. ÇëÒë³öÕâÁ½¾ä»°£¡Ð»Ð»£¡ |
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