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南方科技大学公共卫生及应急管理学院2025级博士研究生招生报考通知

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zhuchunyue

新虫 (初入文坛)

应助: 0 (幼儿园)
金币: 32.1
帖子: 20
在线: 3.7小时
虫号: 1686937
注册: 2012-03-13
专业: 特种医学(航空、航天、航海

[交流] 请问又碰到过小修之后还重新指定审稿人审稿的吗？

投了一个微生物学杂志（Microbiology and Immunology）方面的文章，第一次结果是大修，返修当天结果就是Awaiting reviewer scores，就是送给原审稿人审稿了；
今天早上，结果返回来了是小修，就是几个语法、拼写以及用词问题，不涉及到文章内容问题，结果状态就变成Awaiting reviewer assignment。。。
这是又要重新指派审稿人的节奏吗？？
有点晕乎啊。。
难道是我这次看到小修都是语法错误，重修速度太快了，早上8点给我的修回意见，我中午12点就返修回去了。。。。。
他是下午两点改的这种状态。。哎大意失荆州啊。。

主要是人生第一篇论文，拙计了。。

（因为硬币不多就10个了~ ）

下面是两次返修的意见。。

Major Revision (28-Apr-2015)：

Associate Editor Comments to Author:

Associate Editor
Comments to the Author:
(There are no comments.)

Reviewer(s)' Comments to Author:

Reviewer: 1

Comments to the Author
The manuscript by Zhu et al. evaluated attenuated Salmonella vaccine strain harboring htrA and yncD mutations. The manuscript is understandable but there are several critical points in the manuscript.
(1) Authors should describe the reason why authors chose htrA and yncD double mutant strain for Salmonella enterica serovar Parathyphi A vaccine strain more.
(2) Table 2 is the important result. Authors should show the result more adequately. Describe how many times the experiments were repeated and the mean ± SD.
(3) How can LD50 be estimated by “logistic regression analysis” (page 6, lines 9, 10)?
(4) Many grammatical and careless mistakes are found through the manuscript. I show some examples below.
Page 2, line 9 and others. “the wild-type” is not accurate. “the wild-type strain” is better.
Page 2, lines 10, 11. Add “a” before “human enteric fever vaccine” and “vaccine delivery vector”.
Page 4, line 14. “Kanamycin” reads “kanamycin”.
Page 7, line 4. Remove “assay” after “ELISA”.
Page 8, line 3. “the yncD mutant and the wild-type did” should be “the yncD mutant strain and the wild-type strain”.
Page 8, line 9. Add ”strains” before “(Fig. 2b)”.
Page 8, line 16. Add “,” before “respectively”.
Page 8, line 17. “the wild-type is” should be “the wild-type strain”.
Page 9, line 1. “liter” reads “titer”.
Page 9, line 3. Remove “assay” after “ELISA”.
Page 9, line 4. Remove “did” after “PBS control”.
Page 9, line 9. “mucin mouse model” is strange expression. Just use “mouse model”.
Page 10, line 5. The sentence, “the mutant strains either lose…reduced.” is grammatically wrong.
Page 10, line 13. “and was attenuated” is grammatically wrong.
Page 10, line 2 from the bottom. “Up to date” is strange. “should be to have” should be “should have”.
Page 11, line 3. Add a space between “under” and “development”.
References. Some references use the full journal name and others use the abbreviated form. Follow the author instruction.
Figure legends.
Page 16, line 2. “PCR Identification” reads “PCR identification”.
Page 16, lines 7, 8. “mutant and the wild-type” should be “mutant strain and the wild-type strain”.
Page 16, line 8. “mucin mouse model” should be “mouse model”.
Page 16, line 3 from the bottom. “ELISA assay” should be “ELISA”.
Table 2 (Page 18). In the title of Table 2, “wild-type” should be “wild-type strain” and “mucin mouse model” should be “mouse model”.
Figure 2 (Page 20). The label of y-axis (Lg (CFU/ml)) should be changed. Explanation of “p<0.05” is necessary. Which groups were compared?
Figure 3 (Page 21). It is not necessary to show bar graphs to show LD50. A table is better. Describe SD or SEM.

Reviewer: 2

Comments to the Author
The authors present evidence that double deletion of htrA and yncD on genome of Salmonella enterica serovar Paratyphi A resulted in remarkable decreased virulence compared with that of wild type using mucin mice model. They further show that the double deleted mutant is a candidate as an attenuate vaccine of S. Paratyphi A infection.
This is an interesting work of S. Paratyphi A infection and vaccine. This reviewer has a few questions;

1. Usually, S. Pratyphi A could not infect mouse. The authors should explain about the mucin mice model which they assessed S. Paratyphi A virulence. How does S. Paratyphi A kill mice? Does S. Paratyphi A increase in any organs in mice?

2. It is interested that which gene (htrA or yncD) more contribute to the pathogenicity of S. Paratyphi A. The authors should examine the effect of each gene deletion on S. Paratyphi A virulence.

--------------------------------------------------------我是华丽丽的分水岭-----------------------------------------------------------

Minor Revision (09-Jun-2015)：

Associate Editor Comments to Author:

Associate Editor
Comments to the Author:
(There are no comments.)

Reviewer(s)' Comments to Author:

Reviewer: 1

Comments to the Author
The manuscript by Zhu et al. evaluated attenuated Salmonella vaccine strain harboring htrA and yncD mutations. The manuscript was significantly improved after revision.
I just suggest several corrections.
Page 1, line 20. “Lipopolysaccharide” reads “lipopolysaccharide”.
Page 8, line 164. Remove “Co. Ltd.” Add location of the company.
Page 9, line 169. “Independent-samples T test” should be “Unpaired t test”.
Page 9, line 185. “bacterial sensitivity” should be “bacterial vulnerability”.
Page 10, line 191. “a 33.3% of mortality rate” should be “a mortality rate of 33.3%”.
Page 11, line 229. “produced” should be “observed”.
Page 12, line 244. “stressed” reads “stresses”.
Page 13, line 267. “date” reads “data”.
Page 13, line 269. Use “as…so far” instead of “by now”.
Page 20, line 401. “Independent-samples T test” should be “Unpaired t test”.
Page 21, line 420. “the wild-type strains” reads “the wild-type strain”.
Page 22, Figure 1. Schemas of Figure 1a and Figure 1b are opposite. DK primers are for yncD gene and HK primers are for htrA gene.
Page 27, Table 1. It is better to use capitals (A, G, C, T) instead of small letters (a, g, c, t) for the oligonucleotide sequences.

Reviewer: 2

Comments to the Author
Dear Authors,

Thank you for the revised manuscript. It is shown clearly for my comments.

从小修来看审稿人1 觉得很满意但是提了些小的语法问题审稿人二就是很水的写了句同意他的意思。
按照这个意思，应该会很快就给结果。。
结果重新指定审稿人啷个意思偶。。

[ Last edited by zhuchunyue on 2015-6-10 at 19:17 ]

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