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txy5207: 金币+100, 博学EPI+1, ★★★很有帮助, 100 2012-04-06 22:44:33

In the living organism, many endogenous active materials contain phosphate structure unit, participating in almost all biochemical processes such as material metabolism, energy conversion, and genetic expression of organism, thus the transformation of phosphate on drugs has been one of the hot fields in the modern pharmaceutical research. α-amino phosphonate is used as isostere material of amino acid, and influences physiological metabolism of amino acids through competing with α-amino acids substrate. It can enhance the water-solubility of drugs, promote drug absorption of cells, and relieve cells toxic of drugs, thereby widely being used in design study such as enzyme inhibitor, antibacterial agent, anti-HIV drug, and antitumor drug. Rosin has tricyclic non-hydrophobic group, with higher permeability and low toxicity of cytomembrane. The dehydrogenated rosin acid derivatives have important pharmacological activities of resisting tumor and regulating ion channels

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