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keven7928

至尊木虫 (知名作家)


[资源] Chem Soc Rev上的Conformational changes of non-B DNA

Conformational changes of non-B DNA
In contrast to B-DNA that has a right-handed double helical structure with Watson–Crick base
pairing under the ordinary physiological conditions, repetitive DNA sequences under certain
conditions have the potential to fold into non-B DNA structures such as hairpin, triplex,
cruciform, left-handed Z-form, tetraplex, A-motif, etc. Since the non-B DNA-forming sequences
induce the genetic instability and consequently can cause human diseases, the molecular
mechanism for their genetic instability has been extensively investigated. On the contrary, non-B DNA can be widely used for application in biotechnology because many DNA breakage hotspots are mapped in or near the sequences that have the potential to adopt non-B DNA structures. In addition, they are regarded as a fascinating material for the nanotechnology using non-B DNAs because they do not produce any toxic byproducts and are robust enough for the repetitive
working cycle. This being the case, an understanding on the mechanism and dynamics of their structural changes is important. In this critical review, we describe the latest studies on the conformational dynamics of non-B DNAs, with a focus on G-quadruplex, i-motif, Z-DNA, A-motif, hairpin and triplex (189 references).
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jinhx87

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ding
2楼2011-10-10 13:31:56
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we455

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刚下载了,不错的书
3楼2011-11-03 16:11:58
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