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田鼠117

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[交流] 请帮忙看看这个审稿意见是什么意思?基因治疗方面的,谢谢 已有2人参与

最近投了一篇关于基因治疗方面的文章,下面是审稿人给出的意见,个人感觉挺抽象的,不知道大家有没有什么好的建议?特别是该如何回答呢?谢谢。
Reviewer #1: The results of the authors demonstrated that rAAV2-mediated β-globin virus can efficiently mediate the expression of normal β-globin gene in fetal hematopoietic cells from β-thalassemia patients, for at least 21-35 days in the recipient mice and the level of human β-globin expression significantly increased by 1.2-1.8 folds, as compared with that of controls. So, for the final potential use of rAAV-based clinical gene therapy for human β-thalassemia, more experimental works should be done to answer the questions:
⑴Actually how are the durability and the stability of the rAAV-based transduction? ⑵How is the level of peripheral hemoglobin after the rAAV-based gene therapy?
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liuying_hero

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小木虫(金币+0.5):给个红包,谢谢回帖交流
jackiemwd(金币+1):3ks 2010-08-15 11:11:18
评审认为你的实验结果不够需要更多来验证你下的结论
Kelly
2楼2010-08-15 10:15:05
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田鼠117

银虫 (小有名气)

第一个问题需要补充实验我可以理解。那请问第二个呢?我文章中用HPLC测出了 β与α比值,并证实了相对于对照组,AAV转染可提高该比值,即β链合成增加。那为什么编辑还要再问呢?谢谢
3楼2010-08-15 10:35:41
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