首次投稿，给大修，在补充数据并修改论文后，回复审稿人意见时不清楚该怎么写开头。
Thank you very much for your information. From your letter, we realized that the reviewers feel that major modifications are necessary before publication can be considered. We have answered every question given from the referee.下面要说些什么话呢，是不是要说希望您重新考虑接受之类的，请各位大神指点一下。
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