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thinker98

金虫 (著名写手)

[求助] 第一次投稿,请看这个审稿人的意见,大修吗?

就两个审稿人,其中一个明确写了小修,另一个意见如下,要补实验,但需要补的实验我们没法做

......Therefore, the authors carried out a reverse genetic study to clarify the potential function of *** pathway in ***. They first came out a working model and then tested it step by step. The results were all perfectly supportive to their model and they concluded that***. The study is of interests and may have implication in understanding the molecular mechanism underlying ***.

However, my concern is that their experiments only focused on the working model, which may cause some biases in the result interpretation. For example, if they did not compare the activities of other signaling pathways (including but not limited to MAKP and Insulin pathways) in the ***, how do they know whether lower *** pathway activity in the *** is the major REASON of *** or it is the RESULT of d*** common to most signaling pathways?

I will suggest two experiments.
1). Functional test for *** in pupal development (such as RNAi knock-down of <beta>-catenin and myc in non-diapause pupae).

2). Comparative study of other signaling pathway activities in the *** (such as RNA-seq).
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fengspring

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thinker98: 金币+2 2014-06-01 08:23:19
编辑没说大修,小修吗?从这里看是要按照评审提的修改
好好学习,天天向上
4楼2014-05-28 18:20:42
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岁月神偷

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thinker98: 金币+4 2014-06-01 08:23:05
修改,补充实验后充投,问题不大,给你机会修,认真对待,就会录用

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2楼2014-05-28 17:58:28
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guanlianwu

木虫之王 (文学泰斗)

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thinker98: 金币+2 2014-06-01 08:23:13
好好按要求修改,录用机会还是很大的。
深沉积淀,面朝曙光。
3楼2014-05-28 18:14:45
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thinker98

金虫 (著名写手)

是的,编辑没有具体说大修还是小修,只是一revision。

但第二个编辑提的第一个实验根本做不了;第二个不实际,如果按要求做完,差不多是CNS的水平了,而我投的只是3分多的
5楼2014-05-28 20:56:36
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