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http://apps.webofknowledge.com/f ... age=1&doc=1
Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma


×÷Õß:Chen, HW (Chen, Hongwei)[ 1 ] ; Miao, JL (Miao, Jinlin)[ 2 ] ; Li, HC (Li, Hongchen)[ 1 ] ; Wang, CH (Wang, Chunhua)[ 1 ] ; Li, JL (Li, Junliang)[ 1 ] ; Zhu, Y (Zhu, Yong)[ 1 ] ; Wang, JX (Wang, Jianxin)[ 1 ] ; Wu, X (Wu, Xia)[ 1 ] ; Qiao, HY (Qiao, Hongying)[ 1 ]




JOURNAL OF SURGICAL RESEARCH



¾í: 189

ÆÚ: 1

Ò³: 81-88

DOI: 10.1016/j.jss.2014.01.049

³ö°æÄê: JUN 2014

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Background: p21-activated protein kinase (PAK) 6 is a serine-threonine kinase belonging to the PAK family. Previous studies have indicated that abnormal expressions of PAK1, PAK2, and PAK5 played critical roles in hepatocellular carcinoma (HCC). Recent studies suggested that deregulation of PAK6 expression played an important role in oncogenesis. To explore the potential roles of PAK6 in HCC, expression of PAK6 was detected in human HCC specimens.

Methods: Immunohistochemistry and Western blot analysis were performed for PAK6 in 121 HCC samples. The data were correlated with clinicopathologic features. The univariate and multivariate survival analyses were also performed to determine their clinical prognostic significance.

Results: PAK6 was overexpressed in HCC as compared with the adjacent noncancerous liver tissues. High expression of PAK6 was associated with Edmondson-Steiner grade (P = 0.006) and number of tumor nodules (P < 0.001), and PAK6 was positively correlated with proliferation marker Ki-67 (P < 0.01). Univariate analysis suggested that PAK6 expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that PAK6 and Ki-67 protein expressions were independent prognostic markers for HCC (P = 0.0245 and 0.0331, respectively).

Conclusions: Our results suggest that PAK6 overexpression is involved in the pathogenesis of HCC; it may be an independent poor prognostic factor for HCC. (C) 2014 Elsevier Inc. All rights reserved.


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×÷Õ߹ؼü´Ê:Hepatocellular carcinoma; PAK6; Ki-67; Proliferation

KeyWords Plus:BREAST-CANCER CELLS; COLORECTAL-CANCER; PROTEIN-KINASE; MIGRATION; PAK6; PHOSPHORYLATION; PATHOGENESIS; PROGRESSION; METASTASIS; INVASION


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ͨѶ×÷ÕßµØÖ·: Chen, HW (ͨѶ×÷Õß)



      

First Hosp Qinhuangdao, Dept Clin Lab, 258 Wenhua Rd, Qinhuangdao 066000, Peoples R China.



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[ 1 ] First Hosp Qinhuangdao, Dept Clin Lab, Qinhuangdao 066000, Peoples R China



      

[ 2 ] Fourth Peoples Hosp Taizhou, Dept Magnet Resonance Imaging, Taizhou, Peoples R China



µç×ÓÓʼþµØÖ·:hongweichen0306@outlook.com


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Qinhuangdao Foundation for Development of Science and Technology, China


201302A073

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ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA


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Ñо¿·½Ïò:Surgery

Web of Science Àà±ð:Surgery


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ÎÄÏ×ÀàÐÍ:Article

ÓïÖÖ:English

Èë²ØºÅ: WOS:000334850900011

ISSN: 0022-4804

µç×Ó ISSN: 1095-8673


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Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports&reg;




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