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北京石油化工学院2026年研究生招生接收调剂公告
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oven1986: 检索EPI+1, 感谢应助！ 2014-05-28 22:22:04
http://apps.webofknowledge.com/f ... age=1&doc=1
Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma


作者:Chen, HW (Chen, Hongwei)[ 1 ] ; Miao, JL (Miao, Jinlin)[ 2 ] ; Li, HC (Li, Hongchen)[ 1 ] ; Wang, CH (Wang, Chunhua)[ 1 ] ; Li, JL (Li, Junliang)[ 1 ] ; Zhu, Y (Zhu, Yong)[ 1 ] ; Wang, JX (Wang, Jianxin)[ 1 ] ; Wu, X (Wu, Xia)[ 1 ] ; Qiao, HY (Qiao, Hongying)[ 1 ]




JOURNAL OF SURGICAL RESEARCH



卷: 189

期: 1

页: 81-88

DOI: 10.1016/j.jss.2014.01.049

出版年: JUN 2014

查看期刊信息
































摘要

Background: p21-activated protein kinase (PAK) 6 is a serine-threonine kinase belonging to the PAK family. Previous studies have indicated that abnormal expressions of PAK1, PAK2, and PAK5 played critical roles in hepatocellular carcinoma (HCC). Recent studies suggested that deregulation of PAK6 expression played an important role in oncogenesis. To explore the potential roles of PAK6 in HCC, expression of PAK6 was detected in human HCC specimens.

Methods: Immunohistochemistry and Western blot analysis were performed for PAK6 in 121 HCC samples. The data were correlated with clinicopathologic features. The univariate and multivariate survival analyses were also performed to determine their clinical prognostic significance.

Results: PAK6 was overexpressed in HCC as compared with the adjacent noncancerous liver tissues. High expression of PAK6 was associated with Edmondson-Steiner grade (P = 0.006) and number of tumor nodules (P < 0.001), and PAK6 was positively correlated with proliferation marker Ki-67 (P < 0.01). Univariate analysis suggested that PAK6 expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that PAK6 and Ki-67 protein expressions were independent prognostic markers for HCC (P = 0.0245 and 0.0331, respectively).

Conclusions: Our results suggest that PAK6 overexpression is involved in the pathogenesis of HCC; it may be an independent poor prognostic factor for HCC. (C) 2014 Elsevier Inc. All rights reserved.


关键词

作者关键词:Hepatocellular carcinoma; PAK6; Ki-67; Proliferation

KeyWords Plus:BREAST-CANCER CELLS; COLORECTAL-CANCER; PROTEIN-KINASE; MIGRATION; PAK6; PHOSPHORYLATION; PATHOGENESIS; PROGRESSION; METASTASIS; INVASION


作者信息

通讯作者地址: Chen, HW (通讯作者)



      

First Hosp Qinhuangdao, Dept Clin Lab, 258 Wenhua Rd, Qinhuangdao 066000, Peoples R China.



地址:



      

[ 1 ] First Hosp Qinhuangdao, Dept Clin Lab, Qinhuangdao 066000, Peoples R China



      

[ 2 ] Fourth Peoples Hosp Taizhou, Dept Magnet Resonance Imaging, Taizhou, Peoples R China



电子邮件地址:hongweichen0306@outlook.com


基金资助致谢



基金资助机构

授权号



Qinhuangdao Foundation for Development of Science and Technology, China


201302A073

查看基金资助信息   




出版商

ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA


类别 / 分类

研究方向:Surgery

Web of Science 类别:Surgery


文献信息

文献类型:Article

语种:English

入藏号: WOS:000334850900011

ISSN: 0022-4804

电子 ISSN: 1095-8673


期刊信息


Impact Factor (影响因子): Journal Citation Reports&reg;




其他信息

IDS 号: AF6UU

Web of Science 核心合集中的 "引用的参考文献": 43

Web of Science 核心合集中的 "被引频次": 0
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