²é¿´: 484  |  »Ø¸´: 2
±¾Ìû²úÉú 1 ¸ö LS-EPI £¬µã»÷ÕâÀï½øÐв鿴

chw998

гæ (³õÈëÎÄ̳)

[ÇóÖú] Çë°ïÎÒ²éÒ»ÏÂÎÄÕÂSCIÊÕ¼ºÅ£¬Ð»Ð»£¡

ÇóÖú£¬ÄÄλÄܽøweb of scienceµÄ£¬Çë°ïÎÒ²éһƪÎÄÕÂÊÇ·ñ±»SCIÊÕ¼£¿Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma.J Surg Res. 2014 Jun 1;189(1):81-8. doi: 10.1016/j.jss.2014.01.049. Epub 2014 Jan 29.
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

baiyuefei

°æÖ÷ (ÎÄѧ̩¶·)

·çÑ©

ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÎÄÏ׽ܳö¹±Ï×ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÎÄÏ׽ܳö¹±Ï×ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÎÄÏ׽ܳö¹±Ï×ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
oven1986: ¼ìË÷EPI+1, ¸ÐлӦÖú£¡ 2014-05-28 22:22:04
http://apps.webofknowledge.com/f ... age=1&doc=1
Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma


×÷Õß:Chen, HW (Chen, Hongwei)[ 1 ] ; Miao, JL (Miao, Jinlin)[ 2 ] ; Li, HC (Li, Hongchen)[ 1 ] ; Wang, CH (Wang, Chunhua)[ 1 ] ; Li, JL (Li, Junliang)[ 1 ] ; Zhu, Y (Zhu, Yong)[ 1 ] ; Wang, JX (Wang, Jianxin)[ 1 ] ; Wu, X (Wu, Xia)[ 1 ] ; Qiao, HY (Qiao, Hongying)[ 1 ]




JOURNAL OF SURGICAL RESEARCH



¾í: 189

ÆÚ: 1

Ò³: 81-88

DOI: 10.1016/j.jss.2014.01.049

³ö°æÄê: JUN 2014

²é¿´ÆÚ¿¯ÐÅÏ¢
































ÕªÒª

Background: p21-activated protein kinase (PAK) 6 is a serine-threonine kinase belonging to the PAK family. Previous studies have indicated that abnormal expressions of PAK1, PAK2, and PAK5 played critical roles in hepatocellular carcinoma (HCC). Recent studies suggested that deregulation of PAK6 expression played an important role in oncogenesis. To explore the potential roles of PAK6 in HCC, expression of PAK6 was detected in human HCC specimens.

Methods: Immunohistochemistry and Western blot analysis were performed for PAK6 in 121 HCC samples. The data were correlated with clinicopathologic features. The univariate and multivariate survival analyses were also performed to determine their clinical prognostic significance.

Results: PAK6 was overexpressed in HCC as compared with the adjacent noncancerous liver tissues. High expression of PAK6 was associated with Edmondson-Steiner grade (P = 0.006) and number of tumor nodules (P < 0.001), and PAK6 was positively correlated with proliferation marker Ki-67 (P < 0.01). Univariate analysis suggested that PAK6 expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that PAK6 and Ki-67 protein expressions were independent prognostic markers for HCC (P = 0.0245 and 0.0331, respectively).

Conclusions: Our results suggest that PAK6 overexpression is involved in the pathogenesis of HCC; it may be an independent poor prognostic factor for HCC. (C) 2014 Elsevier Inc. All rights reserved.


¹Ø¼ü´Ê

×÷Õ߹ؼü´Ê:Hepatocellular carcinoma; PAK6; Ki-67; Proliferation

KeyWords Plus:BREAST-CANCER CELLS; COLORECTAL-CANCER; PROTEIN-KINASE; MIGRATION; PAK6; PHOSPHORYLATION; PATHOGENESIS; PROGRESSION; METASTASIS; INVASION


×÷ÕßÐÅÏ¢

ͨѶ×÷ÕßµØÖ·: Chen, HW (ͨѶ×÷Õß)



      

First Hosp Qinhuangdao, Dept Clin Lab, 258 Wenhua Rd, Qinhuangdao 066000, Peoples R China.



µØÖ·:



      

[ 1 ] First Hosp Qinhuangdao, Dept Clin Lab, Qinhuangdao 066000, Peoples R China



      

[ 2 ] Fourth Peoples Hosp Taizhou, Dept Magnet Resonance Imaging, Taizhou, Peoples R China



µç×ÓÓʼþµØÖ·:hongweichen0306@outlook.com


»ù½ð×ÊÖúÖÂл



»ù½ð×ÊÖú»ú¹¹

ÊÚȨºÅ



Qinhuangdao Foundation for Development of Science and Technology, China


201302A073

²é¿´»ù½ð×ÊÖúÐÅÏ¢   




³ö°æÉÌ

ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA


Àà±ð / ·ÖÀà

Ñо¿·½Ïò:Surgery

Web of Science Àà±ð:Surgery


ÎÄÏ×ÐÅÏ¢

ÎÄÏ×ÀàÐÍ:Article

ÓïÖÖ:English

Èë²ØºÅ: WOS:000334850900011

ISSN: 0022-4804

µç×Ó ISSN: 1095-8673


ÆÚ¿¯ÐÅÏ¢


Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports&reg;




ÆäËûÐÅÏ¢

IDS ºÅ: AF6UU

Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 43

Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
2Â¥2014-05-27 16:48:08
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

baiyuefei

°æÖ÷ (ÎÄѧ̩¶·)

·çÑ©

ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÎÄÏ׽ܳö¹±Ï×ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÎÄÏ׽ܳö¹±Ï×ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÎÄÏ׽ܳö¹±Ï×ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¡ï ¡ï ¡ï ¡ï ¡ï
chw998: ½ð±Ò+5 2014-05-27 21:27:49
Èë²ØºÅ: WOS:000334850900011
3Â¥2014-05-27 16:48:23
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ chw998 µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ÉúÎïѧѧ˶Çóµ÷¼Á +5 СÑò˯×ÅÁË? 2026-03-23 5/250 2026-03-24 06:42 by ilovexiaobin
[¿¼ÑÐ] 284Çóµ÷¼Á +10 Zhao anqi 2026-03-22 10/500 2026-03-24 00:08 by Equinoxhua
[¿¼ÑÐ] 341Çóµ÷¼Á(Ò»Ö¾Ô¸ºþÄÏ´óѧ070300) +5 ·¬ÇÑÍ·--- 2026-03-22 6/300 2026-03-23 23:45 by Txy@872106
[¿¼ÑÐ] 085600²ÄÁÏÓ뻯¹¤µ÷¼Á +7 A-¶ßÀ²ZÃÎ 2026-03-23 12/600 2026-03-23 23:16 by ÐÇ¿ÕÐÇÔÂ
[¿¼ÑÐ] ²ÄÁÏר˶ÕÒµ÷¼Á +3 ¹þ¹þ¹þºðºðºð¹þ 2026-03-23 3/150 2026-03-23 23:13 by peike
[¿¼ÑÐ] 336Çóµ÷¼Á +4 ÊÕµ½VS 2026-03-20 4/200 2026-03-23 19:02 by macy2011
[¿¼ÑÐ] 08¹¤Ñ§µ÷¼Á +7 Óû§573181 2026-03-20 11/550 2026-03-23 15:47 by ÎÒ°®Ñ§Ï°Ñ§Ï°Ê¹Î
[¿¼ÑÐ] 293Çóµ÷¼Á +3 ÌÎÌÎWjt 2026-03-22 5/250 2026-03-22 22:21 by jiangpengfei
[¿¼ÑÐ] ѰÕÒµ÷¼Á +4 ¾óǿâ? 2026-03-21 4/200 2026-03-22 16:14 by ľÍÐζ¶
[¿¼ÑÐ] Ò»Ö¾Ô¸±±¾©»¯¹¤´óѧ070300 ѧ˶336Çóµ÷¼Á +5 vvÃÔ 2026-03-21 8/400 2026-03-22 14:20 by ColorlessPI
[¿¼ÑÐ] Çóµ÷¼Á +5 Zhangbod 2026-03-21 7/350 2026-03-22 13:13 by Zhangbod
[¿¼ÑÐ] 279Çóµ÷¼Á +5 ºìÒÂÒþ¹Ù 2026-03-21 5/250 2026-03-21 14:59 by lature00
[¿¼ÑÐ] ²ÄÁÏÓ뻯¹¤£¨0856£©304Çó BÇø µ÷¼Á +3 Çñgl 2026-03-21 3/150 2026-03-21 13:47 by lature00
[¿¼ÑÐ] 332Çóµ÷¼Á +4 ydfyh 2026-03-17 4/200 2026-03-21 02:20 by JourneyLucky
[¿¼ÑÐ] 085700×ÊÔ´Óë»·¾³308Çóµ÷¼Á +12 īīĮ 2026-03-18 13/650 2026-03-21 01:42 by JourneyLucky
[¿¼ÑÐ] 296Çóµ÷¼Á +6 www_q 2026-03-18 10/500 2026-03-20 23:56 by JourneyLucky
[¿¼ÑÐ] ²ÄÁÏÓ뻯¹¤ 322Çóµ÷¼Á +4 È»11 2026-03-19 4/200 2026-03-20 22:12 by luoyongfeng
[¿¼ÑÐ] 0817 »¯Ñ§¹¤³Ì 299·ÖÇóµ÷¼Á ÓпÆÑо­Àú ÓжþÇøÎÄÕ +22 rare12345 2026-03-18 22/1100 2026-03-20 20:39 by zhukairuo
[¿¼ÑÐ] Ò»Ö¾Ô¸ ÄϾ©º½¿Õº½Ìì´óѧ´óѧ £¬080500²ÄÁÏ¿ÆÑ§Ó빤³Ìѧ˶ +5 @taotao 2026-03-20 5/250 2026-03-20 20:16 by JourneyLucky
[¿¼ÑÐ] 261ÇóBÇøµ÷¼Á£¬¿ÆÑо­Àú·á¸» +3 Å£Ä̺Üæ 2026-03-20 4/200 2026-03-20 19:34 by JourneyLucky
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û