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hf1829

木虫 (小有名气)

应助: 0 (幼儿园)
金币: 1864.7
帖子: 86
在线: 4.7小时
虫号: 120956
注册: 2005-12-03
专业: 呼吸系统肿瘤

[交流] 转贴（丁香园）肿瘤学研究生必看的文献

大家好，据我所知，相当部分的研究生做的科研题目与肿瘤有关，但是遗憾的是有许多研究生毕业时对肿瘤的理解还停留在很肤浅的认识层次上，加上许多学校开展的肿瘤课程陈腐老套，耽误了我们很多青年的青春和激情，另外，许多研究生自己选择和设计的题目也不能令自己和他人满意，一个重要原因是对肿瘤的了解非常有限，文献看的太少。由于关于肿瘤的文献超过160万篇，这令许多新手无法下手，在这里，根据我个人对肿瘤的理解，特推荐下列经典文章供新手参考，也希望抛砖引玉，高手们提供更多的文章。

1）癌基因和抑癌基因与肿瘤关系文章：
Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer.Nat Rev Cancer. 2002 May;2(5):331-41. Review.
Hanahan D, Weinberg RA. The hallmarks of cancer.Cell. 2000 Jan 7;100(1):57-70. Review.
Weinberg RA. Tumor suppressor genes.Science. 1991 Nov 22;254(5035):1138-46. Review
Weinberg RA. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.Cancer Res. 1989 Jul 15;49(14):3713-21. Review.
Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis.Science. 1983 Nov 18;222(4625):771-8. Review.
Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer.
Cell. 1996 Oct 18;87(2):159-70. Review.
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis.Cell. 1990 Jun 1;61(5):759-67. Review.
Prehn RT. Many growth factors may not be growth factors.Cancer Res. 1992 Feb 1;52(3):501-7. Review.

2）基因组不稳定与癌
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer. 2003 Sep;3(9):695-701. Review.
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers.
Nature. 1998 Dec 17;396(6712):643-9. Review.
Nowell PC. Mechanisms of tumor progression.Cancer Res. 1986 May;46(5):2203-7. Review
Nowell PC. Tumor progression: a brief historical perspective.Semin Cancer Biol. 2002 Aug;12(4):261-6. Review.
Loeb LA, Loeb KR, Anderson JP. Multiple mutations and cancer.Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81. Epub 2003 Jan 27. Review
Loeb LA. Microsatellite instability: marker of a mutator phenotype in cancer.
Cancer Res. 1994 Oct 1;54(19):5059-63. Review.
3）肿瘤干细胞
Al-Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF. Therapeutic implications of cancer stem cells.Curr Opin Genet Dev. 2004 Feb;14(1):43-7. Review.
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells.Nature. 2001 Nov 1;414(6859):105-11. Review.
Perez-Losada J, Balmain A. Stem-cell hierarchy in skin cancer.Nat Rev Cancer. 2003 Jun;3:434-43. Review.
Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer.Nat Rev Cancer. 2003 Dec;3(12):895-902. Review.

4）肿瘤与端粒
Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer.
J Clin Invest. 2004 Jan;113(2):160-8. Review.
Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer.Science. 2002 Jul 26;297(5581):565-9. Review.
DePinho RA. The age of cancer.Nature. 2000 Nov 9;408(6809):248-54.

5）肿瘤与进化和适应
Farber E. The step-by-step development of epithelial cancer: from phenotype to genotype.Adv Cancer Res. 1996;70:21-48.
Farber E, Rubin H. Cellular adaptation in the origin and development of cancer.
Cancer Res. 1991 Jun 1;51(11):2751-61.
Rubin H. Microenvironmental regulation of the initiated cell.Adv Cancer Res. 2003;90:1-62. Review.
Rubin H. Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.Oncogene. 2002 Oct 21;21(48):7392-411. Review.
Rubin H. Selected cell and selective microenvironment in neoplastic development.
Cancer Res. 2001 Feb 1;61(3):799-807. Review.

6）肿瘤与非整倍体
Duesberg P, Li R. Multistep carcinogenesis: a chain reaction of aneuploidizations.
Cell Cycle. 2003 May-Jun;2(3):202-10. Review.
Li R, Yerganian G, Duesberg P, Kraemer A, Willer A, Rausch C, Hehlmann R. Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells.Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14506-11.
Li R, Sonik A, Stindl R, Rasnick D, Duesberg P. Related Articles, Links
Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy.Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3236-41.

7）肿瘤与免疫
Prehn RT. Stimulatory effects of immune reactions upon the growths of untransplanted tumors.Cancer Res. 1994 Feb 15;54(4):908-14. Review.
Gilboa E. The promise of cancer vaccines.Nat Rev Cancer. 2004 May;4(5):401-11.
8）肿瘤与信号转到以及细胞周期
Blume-Jensen P, Hunter T. Oncogenic kinase signalling.Nature. 2001 May 17;411(6835):355-65. Review.
Hunter T. Oncoprotein networks.Cell. 1997 Feb 7;88(3):333-46. Review.
Hartwell LH, Kastan MB. Cell cycle control and cancer.Science. 1994 Dec 16;266(5192):1821-8. Review.

9）癌的启动和促进
Dlugosz A, Merlino G, Yuspa SH. Progress in cutaneous cancer research.
J Investig Dermatol Symp Proc. 2002 Dec;7(1):17-26. Review
Yuspa SH, Dlugosz AA, Denning MF, Glick AB. Multistage carcinogenesis in the skin.
J Investig Dermatol Symp Proc. 1996 Apr;1(2):147-50.
Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture.Cancer Res. 1994 Mar 1;54(5):1178-89. Review.

10）两次打击
Knudson AG. Two genetic hits (more or less) to cancer.Nat Rev Cancer. 2001 Nov;1(2):157-62.
Knudson AG. Antioncogenes and human cancer.Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10914-21.

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