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´ó¼ÒºÃ£¬¾ÝÎÒËùÖª£¬Ï൱²¿·ÖµÄÑо¿Éú×öµÄ¿ÆÑÐÌâÄ¿ÓëÖ×ÁöÓйأ¬µ«ÊÇÒź¶µÄÊÇÓÐÐí¶àÑо¿Éú±Ïҵʱ¶ÔÖ×ÁöµÄÀí½â»¹Í£ÁôÔںܷôdzµÄÈÏʶ²ã´ÎÉÏ£¬¼ÓÉÏÐí¶àѧУ¿ªÕ¹µÄÖ×Áö¿Î³Ì³Â¸¯ÀÏÌ×£¬µ¢ÎóÁËÎÒÃǺܶàÇàÄêµÄÇà´ººÍ¼¤Ç飬ÁíÍ⣬Ðí¶àÑо¿Éú×Ô¼ºÑ¡ÔñºÍÉè¼ÆµÄÌâĿҲ²»ÄÜÁî×Ô¼ººÍËûÈËÂúÒ⣬һ¸öÖØÒªÔÒòÊǶÔÖ×ÁöµÄÁ˽â·Ç³£ÓÐÏÞ£¬ÎÄÏ׿´µÄÌ«ÉÙ¡£ÓÉÓÚ¹ØÓÚÖ×ÁöµÄÎÄÏ׳¬¹ý160Íòƪ£¬ÕâÁîÐí¶àÐÂÊÖÎÞ·¨ÏÂÊÖ£¬ÔÚÕâÀ¸ù¾ÝÎÒ¸öÈ˶ÔÖ×ÁöµÄÀí½â£¬ÌØÍƼöÏÂÁоµäÎÄÕ¹©ÐÂÊֲο¼£¬Ò²Ï£ÍûÅ×שÒýÓñ£¬¸ßÊÖÃÇÌṩ¸ü¶àµÄÎÄÕ¡£ 1£©°©»ùÒòºÍÒÖ°©»ùÒòÓëÖ×Áö¹ØÏµÎÄÕ£º Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer.Nat Rev Cancer. 2002 May;2(5):331-41. Review. Hanahan D, Weinberg RA. The hallmarks of cancer.Cell. 2000 Jan 7;100(1):57-70. Review. Weinberg RA. Tumor suppressor genes.Science. 1991 Nov 22;254(5035):1138-46. Review Weinberg RA. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.Cancer Res. 1989 Jul 15;49(14):3713-21. Review. Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis.Science. 1983 Nov 18;222(4625):771-8. Review. 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