Znn3bq.jpeg
²é¿´: 1368  |  »Ø¸´: 7
µ±Ç°Ö÷ÌâÒѾ­´æµµ¡£
µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû

hf1829

ľ³æ (СÓÐÃûÆø)

[½»Á÷] תÌù£¨¶¡ÏãÔ°£©Ö×ÁöѧÑо¿Éú±Ø¿´µÄÎÄÏ×

´ó¼ÒºÃ£¬¾ÝÎÒËùÖª£¬Ï൱²¿·ÖµÄÑо¿Éú×öµÄ¿ÆÑÐÌâÄ¿ÓëÖ×ÁöÓйأ¬µ«ÊÇÒź¶µÄÊÇÓÐÐí¶àÑо¿Éú±Ïҵʱ¶ÔÖ×ÁöµÄÀí½â»¹Í£ÁôÔںܷôdzµÄÈÏʶ²ã´ÎÉÏ£¬¼ÓÉÏÐí¶àѧУ¿ªÕ¹µÄÖ×Áö¿Î³Ì³Â¸¯ÀÏÌ×£¬µ¢ÎóÁËÎÒÃǺܶàÇàÄêµÄÇà´ººÍ¼¤Ç飬ÁíÍ⣬Ðí¶àÑо¿Éú×Ô¼ºÑ¡ÔñºÍÉè¼ÆµÄÌâĿҲ²»ÄÜÁî×Ô¼ººÍËûÈËÂúÒ⣬һ¸öÖØÒªÔ­ÒòÊǶÔÖ×ÁöµÄÁ˽â·Ç³£ÓÐÏÞ£¬ÎÄÏ׿´µÄÌ«ÉÙ¡£ÓÉÓÚ¹ØÓÚÖ×ÁöµÄÎÄÏ׳¬¹ý160Íòƪ£¬ÕâÁîÐí¶àÐÂÊÖÎÞ·¨ÏÂÊÖ£¬ÔÚÕâÀ¸ù¾ÝÎÒ¸öÈ˶ÔÖ×ÁöµÄÀí½â£¬ÌØÍƼöÏÂÁо­µäÎÄÕ¹©ÐÂÊֲο¼£¬Ò²Ï£ÍûÅ×שÒýÓñ£¬¸ßÊÖÃÇÌṩ¸ü¶àµÄÎÄÕ¡£

1£©°©»ùÒòºÍÒÖ°©»ùÒòÓëÖ×Áö¹ØÏµÎÄÕ£º
Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer.Nat Rev Cancer. 2002 May;2(5):331-41. Review.
Hanahan D, Weinberg RA. The hallmarks of cancer.Cell. 2000 Jan 7;100(1):57-70. Review.
Weinberg RA. Tumor suppressor genes.Science. 1991 Nov 22;254(5035):1138-46. Review
Weinberg RA. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.Cancer Res. 1989 Jul 15;49(14):3713-21. Review.
Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis.Science. 1983 Nov 18;222(4625):771-8. Review.
Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer.
Cell. 1996 Oct 18;87(2):159-70. Review.
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis.Cell. 1990 Jun 1;61(5):759-67. Review.
Prehn RT. Many growth factors may not be growth factors.Cancer Res. 1992 Feb 1;52(3):501-7. Review.

2£© »ùÒò×é²»Îȶ¨Óë°©
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer. 2003 Sep;3(9):695-701. Review.
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers.
Nature. 1998 Dec 17;396(6712):643-9. Review.
Nowell PC. Mechanisms of tumor progression.Cancer Res. 1986 May;46(5):2203-7. Review
Nowell PC. Tumor progression: a brief historical perspective.Semin Cancer Biol. 2002 Aug;12(4):261-6. Review.
Loeb LA, Loeb KR, Anderson JP. Multiple mutations and cancer.Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81. Epub 2003 Jan 27. Review
Loeb LA. Microsatellite instability: marker of a mutator phenotype in cancer.
Cancer Res. 1994 Oct 1;54(19):5059-63. Review.
3£©Ö×Áö¸Éϸ°û
Al-Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF. Therapeutic implications of cancer stem cells.Curr Opin Genet Dev. 2004 Feb;14(1):43-7. Review.
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells.Nature. 2001 Nov 1;414(6859):105-11. Review.
Perez-Losada J, Balmain A. Stem-cell hierarchy in skin cancer.Nat Rev Cancer. 2003 Jun;3:434-43. Review.
Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer.Nat Rev Cancer. 2003 Dec;3(12):895-902. Review.

4£©Ö×ÁöÓë¶ËÁ£
Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer.
J Clin Invest. 2004 Jan;113(2):160-8. Review.
Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer.Science. 2002 Jul 26;297(5581):565-9. Review.
DePinho RA. The age of cancer.Nature. 2000 Nov 9;408(6809):248-54.

5£©Ö×ÁöÓë½ø»¯ºÍÊÊÓ¦
Farber E. The step-by-step development of epithelial cancer: from phenotype to genotype.Adv Cancer Res. 1996;70:21-48.
Farber E, Rubin H. Cellular adaptation in the origin and development of cancer.
Cancer Res. 1991 Jun 1;51(11):2751-61.
Rubin H. Microenvironmental regulation of the initiated cell.Adv Cancer Res. 2003;90:1-62. Review.
Rubin H. Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.Oncogene. 2002 Oct 21;21(48):7392-411. Review.
Rubin H. Selected cell and selective microenvironment in neoplastic development.
Cancer Res. 2001 Feb 1;61(3):799-807. Review.

6£©Ö×ÁöÓë·ÇÕû±¶Ìå
Duesberg P, Li R. Multistep carcinogenesis: a chain reaction of aneuploidizations.
Cell Cycle. 2003 May-Jun;2(3):202-10. Review.
Li R, Yerganian G, Duesberg P, Kraemer A, Willer A, Rausch C, Hehlmann R. Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells.Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14506-11.
Li R, Sonik A, Stindl R, Rasnick D, Duesberg P. Related Articles, Links
Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy.Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3236-41.

7£©Ö×ÁöÓëÃâÒß
Prehn RT. Stimulatory effects of immune reactions upon the growths of untransplanted tumors.Cancer Res. 1994 Feb 15;54(4):908-14. Review.
Gilboa E. The promise of cancer vaccines.Nat Rev Cancer. 2004 May;4(5):401-11.
8£©Ö×ÁöÓëÐźÅתµ½ÒÔ¼°Ï¸°ûÖÜÆÚ
Blume-Jensen P, Hunter T. Oncogenic kinase signalling.Nature. 2001 May 17;411(6835):355-65. Review.
Hunter T. Oncoprotein networks.Cell. 1997 Feb 7;88(3):333-46. Review.
Hartwell LH, Kastan MB. Cell cycle control and cancer.Science. 1994 Dec 16;266(5192):1821-8. Review.

9£©°©µÄÆô¶¯ºÍ´Ù½ø
Dlugosz A, Merlino G, Yuspa SH. Progress in cutaneous cancer research.
J Investig Dermatol Symp Proc. 2002 Dec;7(1):17-26. Review
Yuspa SH, Dlugosz AA, Denning MF, Glick AB. Multistage carcinogenesis in the skin.
J Investig Dermatol Symp Proc. 1996 Apr;1(2):147-50.
Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture.Cancer Res. 1994 Mar 1;54(5):1178-89. Review.

10£©Á½´Î´ò»÷
Knudson AG. Two genetic hits (more or less) to cancer.Nat Rev Cancer. 2001 Nov;1(2):157-62.
Knudson AG. Antioncogenes and human cancer.Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10914-21.
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

zhx800810

1

²»´í!!!!!!!!!!!!!!!!!!!!!!!!
7Â¥2006-03-02 22:42:12
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
²é¿´È«²¿ 8 ¸ö»Ø´ð

czx

Í­³æ (ÕýʽдÊÖ)

0.5

ÊÕ²ØÁË£¬Áô×ÅÒÔºóÓá£
5Â¥2006-02-12 07:13:24
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

1

Ö§³Ö£¡£¡£¡£¡£¡£¡£¡£¡£¡£¡£¡£¡
6Â¥2006-02-26 21:29:45
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

1

Ö§³Ö£¡£¡£¡£¡£¡£¡£¡£¡£¡£¡£¡
8Â¥2006-03-12 23:31:32
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 291·Öµ÷¼Á +4 Éϰ¶Ð¡Ó¨¼ÓÓÍ 2026-04-09 5/250 2026-04-11 11:49 by zhq0425
[¿¼ÑÐ] 269Çóµ÷¼Á +8 ¹òÇóÊÕÁô¡£ 2026-04-04 8/400 2026-04-11 10:50 by zhq0425
[¿¼ÑÐ] 290Çóµ÷¼Á +8 luoziheng 2026-04-10 8/400 2026-04-11 10:48 by qingpingzhu
[¿¼ÑÐ] µ÷¼Á +19 СÕÅZA 2026-04-10 20/1000 2026-04-10 22:08 by Öí»á·É
[¿¼ÑÐ] 289 ·Ö105500ҩѧר˶Çóµ÷¼Á(ÕÒBÇøÑ§Ð£) +6 °×ÔÆ123456789 2026-04-09 8/400 2026-04-10 21:13 by zhouxiaoyu
[¿¼ÑÐ] 0703»¯Ñ§Çóµ÷¼Á +21 ²»ÖªÃûµÄСئ 2026-04-08 21/1050 2026-04-09 18:55 by l_paradox
[¿¼ÑÐ] Çóµ÷¼Á²ÄÁÏ¿ÆÑ§Ó빤³ÌÒ»Ö¾Ô¸985³õÊÔ365·Ö +5 ²Ä»¯Àî¿É 2026-04-08 5/250 2026-04-09 17:00 by Lilly_Li
[¿¼ÑÐ] 085600²ÄÁÏÓ뻯¹¤×¨Ë¶329 Çóµ÷¼Á +24 ¶îcc 2026-04-06 25/1250 2026-04-09 16:01 by wp06
[¿¼ÑÐ] 349ѧ¿Æ»¯Ñ§045106Çóµ÷¼Á£¬»¯Ñ§Àà¶¼¿ÉÒÔ +8 ±£ºÃ¶®¶® 2026-04-08 8/400 2026-04-09 14:03 by xulei3024
[¿¼ÑÐ] ²ÄÁϹ¤³Ì322 +18 ¹þ¹þ¹þºðºðºð¹þ 2026-04-07 19/950 2026-04-09 10:44 by cymywx
[¿¼ÑÐ] 286Çóµ÷¼Á +19 Faune 2026-04-08 20/1000 2026-04-09 08:36 by ŶŶ123
[¿¼ÑÐ] ²ÄÁϵ÷¼Á +14 Ò»ÑùYWY 2026-04-06 14/700 2026-04-08 23:00 by Öí»á·É
[¿¼ÑÐ] ²ÄÁϵ÷¼Á +13 ºº123456 2026-04-07 14/700 2026-04-07 22:53 by À´¿´Á÷ÐÇÓê10
[¿¼ÑÐ] 316Çóµ÷¼Á +4 15318418673 2026-04-07 4/200 2026-04-07 22:12 by hemengdong
[¿¼ÑÐ] ÉúÎïѧ363µ÷¼ÁÇóÖú +7 fanzhang6666 2026-04-06 9/450 2026-04-07 17:37 by lijunpoly
[¿¼ÑÐ] 325 µ÷¼Á +6 QQСϺ 2026-04-07 6/300 2026-04-07 15:17 by Ccclqqq
[¿¼ÑÐ] 328Çóµ÷¼Á +4 ghhh88888 2026-04-06 5/250 2026-04-07 14:45 by ghhh88888
[¿¼ÑÐ] Çóµ÷¼Á +7 ÕÅ.1 2026-04-05 7/350 2026-04-05 20:40 by à£à£à£0119
[¿¼ÑÐ] 315Çóµ÷¼Á +5 £¦123456789 2026-04-05 5/250 2026-04-05 19:55 by nepu_uu
[¿¼ÑÐ] ÉúÎïѧ308·ÖÇóµ÷¼Á£¨Ò»Ö¾Ô¸»ª¶«Ê¦´ó£© +8 ÏàÐűػá¹ââÍòÕ 2026-04-05 10/500 2026-04-05 12:19 by Hdyxbekcb
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û