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Dear XXX,

we regret to inform you that on the basis of the reports and comments received from the referees we are unable to accept the above-mentioned manuscript for publication in XXX in its present form.

The comments of the referees are enclosed for your consideration. We hope the information provided by the referees is helpful to you. However, as suggested by the referees, we would like to encourage you to prepare a new version of your manuscript and to resubmit this to the Journal if you have made a thorough revision and you are confident in convincing the referees. But for that you must do the additional experimental work asked by the reviewers. If this is not done, it is not useful to resubmit : your manuscript will be rejected.

If or when you resubmit please have a detailed list (point to point) of your responses to each item of the review comments, and highlight your revised text in red in the new version of your manuscript.

When you do so, please enter the original Manuscript ID in the appropriate field in the manuscript details page.

If we may be of assistance, please feel free to contact us.

Yours sincerely
XXX

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