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fxysnd: ½ð±Ò+5, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2015-04-20 17:13:19
sunshan4379: LS-EPI+1, ¸ÐлӦÖú£¡ 2015-04-20 17:49:10
Prophage-like elements present in Mycobacterium genomes
×÷Õß:Fan, XY (Fan, Xiangyu)[ 1 ] ; Xie, LX (Xie, Longxiang)[ 1 ] ; Li, W (Li, Wu)[ 1 ] ; Xie, JP (Xie, Jianping)[ 1 ]
BMC GENOMICS
¾í: 15
ÎÄÏ׺Å: 243
DOI: 10.1186/1471-2164-15-243
³ö°æÄê: MAR 27 2014
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Background: Prophages, integral components of many bacterial genomes, play significant roles in cognate host bacteria, such as virulence, toxin biosynthesis and secretion, fitness cost, genomic variations, and evolution. Many prophages and prophage-like elements present in sequenced bacterial genomes, such as Bifidobacteria, Lactococcus and Streptococcus, have been described. However, information for the prophage of Mycobacterium remains poorly defined.

Results: In this study, based on the search of the complete genome database from GenBank, the Whole Genome Shotgun (WGS) databases, and some published literatures, thirty-three prophages were described in detail. Eleven of them were full-length prophages, and others were prophage-like elements. Eleven prophages were firstly revealed. They were phiMAV_1, phiMAV_2, phiMmcs_1, phiMmcs_2, phiMkms_1, phiMkms_2, phiBN42_1, phiBN44_1, phiMCAN_1, phiMycsm_1, and phiW7S_1. Their genomes and gene contents were firstly analyzed. Furthermore, comparative genomics analyses among mycobacterioprophages showed that full-length prophage phi172_2 belonged to mycobacteriophage Cluster A and the phiMmcs_1, phiMkms_1, phiBN44_1, and phiMCAN_1 shared high homology and could be classified into one group.

Conclusions: To our knowledge, this is the first systematic characterization of mycobacterioprophages, their genomic organization and phylogeny. This information will afford more understanding of the biology of Mycobacterium.
¹Ø¼ü´Ê
×÷Õ߹ؼü´Êrophage; Mycobacterioprophage; Phylogeny; Comparative genomics
KeyWords Plus:VI SECRETION SYSTEM; PROVIDES INSIGHTS; SEQUENCES; STRAIN; TUBERCULOSIS; INTEGRATION; EVOLUTION; ABSCESSUS; GENES; TOOL
×÷ÕßÐÅÏ¢
ͨѶ×÷ÕßµØÖ·: Xie, JP (ͨѶ×÷Õß)
              Southwest Univ, State Key Lab Breeding Base Gorges Ecoenvironm &, Ecoenvironm Key Lab Gorges Reservoir Reg 3, Inst Modern Biopharmaceut,Minist Educ,Sch Life Sc, Chongqing 400715, Peoples R China.
µØÖ·:
              [ 1 ] Southwest Univ, State Key Lab Breeding Base Gorges Ecoenvironm &, Ecoenvironm Key Lab Gorges Reservoir Reg 3, Inst Modern Biopharmaceut,Minist Educ,Sch Life Sc, Chongqing 400715, Peoples R China
µç×ÓÓʼþµØÖ·:georgex@swu.edu.cn
»ù½ð×ÊÖúÖÂл
»ù½ð×ÊÖú»ú¹¹        ÊÚȨºÅ
National Natural Science Foundation        
81371851
81071316
81271882
81301394
New Century Excellent Talents in Universities        
NCET-11-0703
National Megaprojects for Key Infectious Diseases        
2008ZX10003-006
Excellent PhD thesis fellowship of southwest university        
kb2010017
ky2011003
Fundamental Research Funds for the Central Universities        
XDJK2011D006
XDJK2012D011
XDJK2012D007
XDJK2013D003
XDJK2014D040
Chongqing municipal committee of Education for postgraduates excellence program        
YJG123104
undergraduates teaching reform program        
2011JY052
²é¿´»ù½ð×ÊÖúÐÅÏ¢   
³ö°æÉÌ
BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
Àà±ð / ·ÖÀà
Ñо¿·½Ïò:Biotechnology & Applied Microbiology; Genetics & Heredity
Web of Science Àà±ð:Biotechnology & Applied Microbiology; Genetics & Heredity
ÎÄÏ×ÐÅÏ¢
ÎÄÏ×ÀàÐÍ:Article
ÓïÖÖ:English
Èë²ØºÅ: WOS:000334951800001
PubMed ID: 24673856
ISSN: 1471-2164
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Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®
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Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 38
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
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