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【答案】应助回帖
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感谢参与，应助指数 +1
fxysnd: 金币+5, ★★★★★最佳答案 2015-04-20 17:13:19
sunshan4379: LS-EPI+1, 感谢应助！ 2015-04-20 17:49:10
Prophage-like elements present in Mycobacterium genomes
作者:Fan, XY (Fan, Xiangyu)[ 1 ] ; Xie, LX (Xie, Longxiang)[ 1 ] ; Li, W (Li, Wu)[ 1 ] ; Xie, JP (Xie, Jianping)[ 1 ]
BMC GENOMICS
卷: 15
文献号: 243
DOI: 10.1186/1471-2164-15-243
出版年: MAR 27 2014
查看期刊信息
摘要
Background: Prophages, integral components of many bacterial genomes, play significant roles in cognate host bacteria, such as virulence, toxin biosynthesis and secretion, fitness cost, genomic variations, and evolution. Many prophages and prophage-like elements present in sequenced bacterial genomes, such as Bifidobacteria, Lactococcus and Streptococcus, have been described. However, information for the prophage of Mycobacterium remains poorly defined.
Results: In this study, based on the search of the complete genome database from GenBank, the Whole Genome Shotgun (WGS) databases, and some published literatures, thirty-three prophages were described in detail. Eleven of them were full-length prophages, and others were prophage-like elements. Eleven prophages were firstly revealed. They were phiMAV_1, phiMAV_2, phiMmcs_1, phiMmcs_2, phiMkms_1, phiMkms_2, phiBN42_1, phiBN44_1, phiMCAN_1, phiMycsm_1, and phiW7S_1. Their genomes and gene contents were firstly analyzed. Furthermore, comparative genomics analyses among mycobacterioprophages showed that full-length prophage phi172_2 belonged to mycobacteriophage Cluster A and the phiMmcs_1, phiMkms_1, phiBN44_1, and phiMCAN_1 shared high homology and could be classified into one group.
Conclusions: To our knowledge, this is the first systematic characterization of mycobacterioprophages, their genomic organization and phylogeny. This information will afford more understanding of the biology of Mycobacterium.
关键词
作者关键词 rophage; Mycobacterioprophage; Phylogeny; Comparative genomics
KeyWords Plus:VI SECRETION SYSTEM; PROVIDES INSIGHTS; SEQUENCES; STRAIN; TUBERCULOSIS; INTEGRATION; EVOLUTION; ABSCESSUS; GENES; TOOL
作者信息
通讯作者地址: Xie, JP (通讯作者)
Southwest Univ, State Key Lab Breeding Base Gorges Ecoenvironm &, Ecoenvironm Key Lab Gorges Reservoir Reg 3, Inst Modern Biopharmaceut,Minist Educ,Sch Life Sc, Chongqing 400715, Peoples R China.
地址:
[ 1 ] Southwest Univ, State Key Lab Breeding Base Gorges Ecoenvironm &, Ecoenvironm Key Lab Gorges Reservoir Reg 3, Inst Modern Biopharmaceut,Minist Educ,Sch Life Sc, Chongqing 400715, Peoples R China
电子邮件地址:georgex@swu.edu.cn
基金资助致谢
基金资助机构 授权号
National Natural Science Foundation
81371851
81071316
81271882
81301394
New Century Excellent Talents in Universities
NCET-11-0703
National Megaprojects for Key Infectious Diseases
2008ZX10003-006
Excellent PhD thesis fellowship of southwest university
kb2010017
ky2011003
Fundamental Research Funds for the Central Universities
XDJK2011D006
XDJK2012D011
XDJK2012D007
XDJK2013D003
XDJK2014D040
Chongqing municipal committee of Education for postgraduates excellence program
YJG123104
undergraduates teaching reform program
2011JY052
查看基金资助信息
出版商
BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
类别 / 分类
研究方向:Biotechnology & Applied Microbiology; Genetics & Heredity
Web of Science 类别:Biotechnology & Applied Microbiology; Genetics & Heredity
文献信息
文献类型:Article
语种:English
入藏号: WOS:000334951800001
PubMed ID: 24673856
ISSN: 1471-2164
期刊信息
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: AF8FU
Web of Science 核心合集中的 "引用的参考文献": 38
Web of Science 核心合集中的 "被引频次": 0 |
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