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012006006211гæ (³õÈëÎÄ̳)
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ÇóÎÄÏ× Binding, activation and modulation of Cys-loop receptors ÒÑÓÐ1È˲ÎÓë
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лл´ó¸çÃÇ ×÷Õß Paul S Miller, Trevor G Smart ·¢±íÈÕÆÚ 2010/4/30 ÆÚ¿¯ Trends in pharmacological sciences ¾íºÅ 31 ÆÚºÅ 4 Ò³Â뷶Χ 161-174 ³ö°æÉÌ Elsevier Current Trends ¼ò½é It is over forty years since the major neurotransmitters and their protein receptors were identified, and over twenty years since determination of the first amino-acid sequences of the Cys-loop receptors that recognize acetylcholine, serotonin, GABA and glycine. The last decade has seen the first structures of these proteins (and related bacterial and molluscan homologues) determined to atomic resolution. Hopefully over the next decade, more detailed molecular structures of entire Cys-loop receptors in drug-bound and drug-free ... |
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