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[ÇóÖú] ÇóÎÄÏ× Binding, activation and modulation of Cys-loop receptors ÒÑÓÐ1È˲ÎÓë

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Paul S Miller, Trevor G Smart
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2010/4/30
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Trends in pharmacological sciences
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31
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161-174
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Elsevier Current Trends
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It is over forty years since the major neurotransmitters and their protein receptors were
identified, and over twenty years since determination of the first amino-acid sequences of the
Cys-loop receptors that recognize acetylcholine, serotonin, GABA and glycine. The last
decade has seen the first structures of these proteins (and related bacterial and molluscan
homologues) determined to atomic resolution. Hopefully over the next decade, more
detailed molecular structures of entire Cys-loop receptors in drug-bound and drug-free ...
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