| 查看: 1782 | 回复: 5 | ||||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||||
lyf1023aaa新虫 (初入文坛)
|
[交流]
硫酸沙丁胺醇美国药典检测方法 已有2人参与
|
|||
各位大侠，哪位知道美国药典36,37版本中沙丁胺醇有关物质的检测色谱条件，跪求，谢了。。。。 |
回复此楼» 收录本帖的淘帖专辑推荐
 颛顼药学 |
» 猜你喜欢
105500药学调剂，一志愿顶9，主持省级大创，实验型SCI二作，四六级已过，双国奖
已经有6人回复
-
药学专硕调剂
已经有0人回复
-
药物学论文润色/翻译怎么收费?
已经有184人回复
-
publcif的使用
已经有0人回复
-
求调剂
已经有2人回复
-
会计专硕求调剂
已经有0人回复
-
新加坡国立大学药学系化学生物学课题组招PhD
已经有14人回复
-
请教酰胺缩合反应
已经有4人回复
-
一志愿大连理工制药工程专硕086002，本科211，总分342
已经有0人回复
-
制药工程专业招收调剂，要求过国家线
已经有0人回复
lyf1023aaa
新虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 1515.5
- 红花: 1
- 帖子: 32
- 在线: 44.1小时
- 虫号: 2008057
- 注册: 2012-09-17
- 专业: 无机材料化学
3楼2014-08-01 08:33:25
dingjinglvde
木虫 (正式写手)
- 应助: 41 (小学生)
- 金币: 4351.6
- 红花: 4
- 帖子: 734
- 在线: 653.7小时
- 虫号: 411754
- 注册: 2007-06-24
- 性别: GG
- 专业: 药学
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
Assay— 0.05 ± 0.01 M Ammonium acetate solution— Dissolve 3.85 g of ammonium acetate in 1000 mL of water, and mix. Mobile phase— Prepare a degassed mixture of water, 0.05 ± 0.01 M Ammonium acetate solution, and isopropanol [65: 30: (5 ± 1)], and adjust dropwise with acetic acid to a pH of 4.5 ± 0.3. Resolution solution— Dissolve accurately weighed quantities of USP Albuterol Sulfate RS and USP Albuterol Related Compound A RS in water, and dilute quantitatively, and stepwise if necessary, with Mobile phase to obtain a solution having a known concentration of about 0.140 mg per mL and 0.030 mg per mL, respectively. Standard preparation— Dissolve an accurately weighed quantity of USP Albuterol Sulfate RS in water, and dilute quantitatively with water to obtain a solution having a known concentration of about 0.6 mg per mL. Assay preparation— Transfer about 60 mg of Albuterol Sulfate, accurately weighed, to a 100-mL volumetric flask, dissolve in and dilute with water to volume, and mix. Chromatographic system (see Chromatography 621)— The liquid chromatograph is equipped with a 276-nm detector and a 4.6-mm × 20-cm column that contains packing L10. The flow rate is about 2.0 mL per minute. Chromatograph the Resolution solution, and record the peak responses as directed for Procedure: the resolution, R, between albuterol and albuterol related compound A is not less than 1.5; and the relative standard deviation for replicate injections is not more than 1.5%. Procedure— Separately inject equal volumes (about 10 µL) of the Standard preparation and the Assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. Calculate the quantity, in mg, of (C13H21NO3)2·H2SO4 in the portion of Albuterol Sulfate taken by the formula: 100C(rU / rS) in which C is the concentration, in mg per mL, of USP Albuterol Sulfate RS in the Standard preparation; and rU and rS are the peak responses obtained from the Assay preparation and the Standard preparation, respectively. |
4楼2014-08-01 11:02:55
lyf1023aaa
新虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 1515.5
- 红花: 1
- 帖子: 32
- 在线: 44.1小时
- 虫号: 2008057
- 注册: 2012-09-17
- 专业: 无机材料化学
5楼2014-08-01 15:33:34
dingjinglvde
木虫 (正式写手)
- 应助: 41 (小学生)
- 金币: 4351.6
- 红花: 4
- 帖子: 734
- 在线: 653.7小时
- 虫号: 411754
- 注册: 2007-06-24
- 性别: GG
- 专业: 药学
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
USP35 Assay— 0.05 ± 0.01 M Ammonium acetate solution—Dissolve 3.85 g of ammonium acetate in 1000 mL of water, and mix. Mobile phase—Prepare a degassed mixture of water, 0.05 ± 0.01 M Ammonium acetate solution, and isopropanol [65: 30: (5 ± 1)], and adjust dropwise with acetic acid to a pH of 4.5 ± 0.3. Resolution solution—Dissolve accurately weighed quantities of USP Albuterol Sulfate RS and USP Albuterol Related Compound A RS in water, and dilute quantitatively, and stepwise if neces- sary, with Mobile phase to obtain a solution having a known concentration of about 0.140 mg per mL and 0.030 mg per mL, respectively. Standard preparation—Dissolve an accurately weighed quan- tity of USP Albuterol Sulfate RS in water, and dilute quantita- tively with water to obtain a solution having a known concen- tration of about 0.6 mg per mL. Assay preparation—Transfer about 60 mg of Albuterol Sul- fate, accurately weighed, to a 100-mL volumetric flask, dissolve in and dilute with water to volume, and mix. Chromatographic system (see Chromatography 〈621〉  —Theliquid chromatograph is equipped with a 276-nm detector and a 4.6-mm × 20-cm column that contains packing L10. The flow rate is about 2.0 mL per minute. Chromatograph the Resolution solution, and record the peak responses as directed for Proce- dure: the resolution, R, between albuterol and albuterol related compound A is not less than 1.5; and the relative standard deviation for replicate injections is not more than 1.5%. Procedure—Separately inject equal volumes (about 10 µL) of the Standard preparation and the Assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. Calculate the quantity, in mg, of (C13H21NO3)2 · H2SO4 in the portion of Albuterol Sulfate taken by the formula: 100C(rU / rS) in which C is the concentration, in mg per mL, of USP Albuterol Sulfate RS in the Standard preparation; and rU and rS are the peak responses obtained from the Assay preparation and the Standard preparation, respectively. |
6楼2014-08-01 16:27:58
