| 查看: 1778 | 回复: 5 | ||||
lyf1023aaa新虫 (初入文坛)
|
[交流]
硫酸沙丁胺醇美国药典检测方法 已有2人参与
|
各位大侠，哪位知道美国药典36,37版本中沙丁胺醇有关物质的检测色谱条件，跪求，谢了。。。。 |
回复此楼» 收录本帖的淘帖专辑推荐
 颛顼药学 |
» 猜你喜欢
一志愿天中医中药学专硕，希望有b区的老师可以考虑一下我
已经有1人回复
-
调剂
已经有3人回复
-
药物学论文润色/翻译怎么收费?
已经有96人回复
-
药学学硕326求调剂
已经有0人回复
-
26年博士申请
已经有20人回复
-
药理学、临床药学方向 调剂
已经有1人回复
-
求助 苯磷硫胺JP
已经有0人回复
-
100金币 阿莫西林克拉维酸钾片BP药典中提到的克拉维酸聚合物具体结构式是啥？
已经有2人回复
-
膳食补充剂合规性交流
已经有0人回复
-
一志愿浙大药学求调剂
已经有0人回复
-
高温高压反应求助
已经有2人回复
2楼2014-07-31 13:37:24
lyf1023aaa
新虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 1515.5
- 红花: 1
- 帖子: 32
- 在线: 44.1小时
- 虫号: 2008057
- 注册: 2012-09-17
- 专业: 无机材料化学
3楼2014-08-01 08:33:25
dingjinglvde
木虫 (正式写手)
- 应助: 41 (小学生)
- 金币: 4351.6
- 红花: 4
- 帖子: 734
- 在线: 653.7小时
- 虫号: 411754
- 注册: 2007-06-24
- 性别: GG
- 专业: 药学
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
Assay— 0.05 ± 0.01 M Ammonium acetate solution— Dissolve 3.85 g of ammonium acetate in 1000 mL of water, and mix. Mobile phase— Prepare a degassed mixture of water, 0.05 ± 0.01 M Ammonium acetate solution, and isopropanol [65: 30: (5 ± 1)], and adjust dropwise with acetic acid to a pH of 4.5 ± 0.3. Resolution solution— Dissolve accurately weighed quantities of USP Albuterol Sulfate RS and USP Albuterol Related Compound A RS in water, and dilute quantitatively, and stepwise if necessary, with Mobile phase to obtain a solution having a known concentration of about 0.140 mg per mL and 0.030 mg per mL, respectively. Standard preparation— Dissolve an accurately weighed quantity of USP Albuterol Sulfate RS in water, and dilute quantitatively with water to obtain a solution having a known concentration of about 0.6 mg per mL. Assay preparation— Transfer about 60 mg of Albuterol Sulfate, accurately weighed, to a 100-mL volumetric flask, dissolve in and dilute with water to volume, and mix. Chromatographic system (see Chromatography 621)— The liquid chromatograph is equipped with a 276-nm detector and a 4.6-mm × 20-cm column that contains packing L10. The flow rate is about 2.0 mL per minute. Chromatograph the Resolution solution, and record the peak responses as directed for Procedure: the resolution, R, between albuterol and albuterol related compound A is not less than 1.5; and the relative standard deviation for replicate injections is not more than 1.5%. Procedure— Separately inject equal volumes (about 10 µL) of the Standard preparation and the Assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. Calculate the quantity, in mg, of (C13H21NO3)2·H2SO4 in the portion of Albuterol Sulfate taken by the formula: 100C(rU / rS) in which C is the concentration, in mg per mL, of USP Albuterol Sulfate RS in the Standard preparation; and rU and rS are the peak responses obtained from the Assay preparation and the Standard preparation, respectively. |
4楼2014-08-01 11:02:55
lyf1023aaa
新虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 1515.5
- 红花: 1
- 帖子: 32
- 在线: 44.1小时
- 虫号: 2008057
- 注册: 2012-09-17
- 专业: 无机材料化学
5楼2014-08-01 15:33:34
dingjinglvde
木虫 (正式写手)
- 应助: 41 (小学生)
- 金币: 4351.6
- 红花: 4
- 帖子: 734
- 在线: 653.7小时
- 虫号: 411754
- 注册: 2007-06-24
- 性别: GG
- 专业: 药学
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
USP35 Assay— 0.05 ± 0.01 M Ammonium acetate solution—Dissolve 3.85 g of ammonium acetate in 1000 mL of water, and mix. Mobile phase—Prepare a degassed mixture of water, 0.05 ± 0.01 M Ammonium acetate solution, and isopropanol [65: 30: (5 ± 1)], and adjust dropwise with acetic acid to a pH of 4.5 ± 0.3. Resolution solution—Dissolve accurately weighed quantities of USP Albuterol Sulfate RS and USP Albuterol Related Compound A RS in water, and dilute quantitatively, and stepwise if neces- sary, with Mobile phase to obtain a solution having a known concentration of about 0.140 mg per mL and 0.030 mg per mL, respectively. Standard preparation—Dissolve an accurately weighed quan- tity of USP Albuterol Sulfate RS in water, and dilute quantita- tively with water to obtain a solution having a known concen- tration of about 0.6 mg per mL. Assay preparation—Transfer about 60 mg of Albuterol Sul- fate, accurately weighed, to a 100-mL volumetric flask, dissolve in and dilute with water to volume, and mix. Chromatographic system (see Chromatography 〈621〉  —Theliquid chromatograph is equipped with a 276-nm detector and a 4.6-mm × 20-cm column that contains packing L10. The flow rate is about 2.0 mL per minute. Chromatograph the Resolution solution, and record the peak responses as directed for Proce- dure: the resolution, R, between albuterol and albuterol related compound A is not less than 1.5; and the relative standard deviation for replicate injections is not more than 1.5%. Procedure—Separately inject equal volumes (about 10 µL) of the Standard preparation and the Assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. Calculate the quantity, in mg, of (C13H21NO3)2 · H2SO4 in the portion of Albuterol Sulfate taken by the formula: 100C(rU / rS) in which C is the concentration, in mg per mL, of USP Albuterol Sulfate RS in the Standard preparation; and rU and rS are the peak responses obtained from the Assay preparation and the Standard preparation, respectively. |
6楼2014-08-01 16:27:58
