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LI Yan,TANG He-Xin, GAO Hai-Taob, HU Yang-Gen, Synthesis, Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo[2,3-d] pyrimidine-6-carboxylate, 结 构 化 学 （JIEGOU HUAXUE),Vol. 32, No. 12. |
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baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★
sunshan4379: 检索EPI+1, 感谢应助！ 2014-07-07 18:54:09
junren751113(sunshan4379代发): 金币+10 2014-07-19 17:26:33
sunshan4379: 检索EPI+1, 感谢应助！ 2014-07-07 18:54:09
junren751113(sunshan4379代发): 金币+10 2014-07-19 17:26:33
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Synthesis, Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo [2,3-d] pyrimidine-6-carboxylate 作者:Li, Y (Li Yan)[ 1 ] ; Tang, HX (Tang He-Xin)[ 2,3 ] ; Gao, HT (Gao Hai-Tao)[ 2 ] ; Hu, YG (Hu Yang-Gen)[ 2,3 ] CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 卷: 32 期: 12 页: 1868-1872 出版年: 2013 查看期刊信息 摘要 The title compound (C21H24N4O4, M-r = 396.44) has been synthesized by the functionalized ethyl 4-chloro-6-methyl-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylates and morpholine. Its structure was confirmed by means of H-1 NMR JR. MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P (1) over bar, a = 7.9919(8), b = 9.9312(1), c = 12.9380(13) angstrom, alpha = 86.987(2), beta = 83.604(2), gamma = 89.641(2)degrees, V = 1019.08(18) angstrom(3), Z = 2, F(000) = 420, D-c = 1.292 g/cm(3), mu = 0.091 mm(-1), R = 0.0602 and wR = 0.1548 for 3943 independent (R-int = 0.0639) and 3414 observed (I > 2 sigma(I)) reflections. Intermolecular N-H center dot center dot center dot O and pi-pi stacking interactions contributed to the stability of the structure. The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines. 关键词 作者关键词:furo[2,3-d]pyrimidine; synthesis; crystal structure; antitumor activity KeyWords Plus:THYMIDYLATE SYNTHASE; EFFICIENT SYNTHESIS; LUNG-CANCER; INHIBITORS; TARGET 作者信息 通讯作者地址: Hu, YG (通讯作者) Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China. 地址: [ 1 ] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem & Biol, Xianning 437100, Peoples R China [ 2 ] Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China [ 3 ] Hubei Univ Med, Taihe Hosp, Shiyan 442000, Peoples R China 电子邮件地址:ygh6686@aliyun.com 基金资助致谢 基金资助机构 授权号 Natural Science Foundation of Hubei Provincial Department of Science and Technology 2011CDB08301 Science Research Project of Hubei University of Medicine 2011 CXX03 2609QDJ15 查看基金资助信息 出版商 CHINESE JOURNAL STRUCTURAL CHEMISTRY, FUIJAN INST RES STRUCT MATTER, CHINESE ACAD SCIENCES, FUZHOU, FUJIAN 350002, PEOPLES R CHINA 类别 / 分类 研究方向:Chemistry; Crystallography Web of Science 类别:Chemistry, Inorganic & Nuclear; Crystallography 文献信息 文献类型:Article 语种:English 入藏号: WOS:000329421300015 ISSN: 0254-5861 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: 285UU Web of Science 核心合集中的 "引用的参考文献": 17 Web of Science 核心合集中的 "被引频次": 0 |
3楼2014-06-22 09:02:47
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4643 (副教授)
- 贵宾: 46.97
- 金币: 659303
- 散金: 11616
- 红花: 995
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- 帖子: 69593
- 在线: 13493.5小时
- 虫号: 676696
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- 专业: 合成药物化学
- 管辖: 有机交流
2楼2014-06-22 09:02:36
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4643 (副教授)
- 贵宾: 46.97
- 金币: 659303
- 散金: 11616
- 红花: 995
- 沙发: 81
- 帖子: 69593
- 在线: 13493.5小时
- 虫号: 676696
- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
- 管辖: 有机交流
4楼2014-06-22 09:03:21
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