24小时热门版块排行榜

返回列表

本帖产生 1 个 LS-EPI ，点击这里进行查看

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

junren751113

铜虫 (初入文坛)

应助: 0 (幼儿园)
金币: 76.5
帖子: 49
在线: 12.4小时
虫号: 448934
注册: 2007-11-02
专业: 计算数学

[求助] 求一篇论文的检索情况！

LI Yan,TANG He-Xin, GAO Hai-Taob, HU Yang-Gen, Synthesis, Crystal Structure and Antitumor
Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo[2,3-d]
pyrimidine-6-carboxylate, 结构化学（JIEGOU HUAXUE),Vol. 32, No. 12.

回复此楼

» 猜你喜欢

1楼 2014-06-22 08:12:25

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

baiyuefei

版主 (文学泰斗)

风雪

LS-EPI: 1647
应助: 4642 (副教授)
贵宾: 46.969
金币: 658099
散金: 11616
红花: 995
沙发: 81
帖子: 69384
在线: 13283.5小时
虫号: 676696
注册: 2008-12-18
性别: GG
专业: 合成药物化学
管辖: 有机交流

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★
sunshan4379: 检索EPI+1, 感谢应助！ 2014-07-07 18:54:09
junren751113(sunshan4379代发): 金币+10 2014-07-19 17:26:33

Synthesis, Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo [2,3-d] pyrimidine-6-carboxylate

作者:Li, Y (Li Yan)[ 1 ] ; Tang, HX (Tang He-Xin)[ 2,3 ] ; Gao, HT (Gao Hai-Tao)[ 2 ] ; Hu, YG (Hu Yang-Gen)[ 2,3 ]

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY

卷: 32

期: 12

页: 1868-1872

出版年: 2013

查看期刊信息

摘要

The title compound (C21H24N4O4, M-r = 396.44) has been synthesized by the functionalized ethyl 4-chloro-6-methyl-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylates and morpholine. Its structure was confirmed by means of H-1 NMR JR. MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P (1) over bar, a = 7.9919(8), b = 9.9312(1), c = 12.9380(13) angstrom, alpha = 86.987(2), beta = 83.604(2), gamma = 89.641(2)degrees, V = 1019.08(18) angstrom(3), Z = 2, F(000) = 420, D-c = 1.292 g/cm(3), mu = 0.091 mm(-1), R = 0.0602 and wR = 0.1548 for 3943 independent (R-int = 0.0639) and 3414 observed (I > 2 sigma(I)) reflections. Intermolecular N-H center dot center dot center dot O and pi-pi stacking interactions contributed to the stability of the structure. The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines.

关键词

作者关键词:furo[2,3-d]pyrimidine; synthesis; crystal structure; antitumor activity

KeyWords Plus:THYMIDYLATE SYNTHASE; EFFICIENT SYNTHESIS; LUNG-CANCER; INHIBITORS; TARGET

作者信息

通讯作者地址: Hu, YG (通讯作者)



Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China.

地址:



[ 1 ] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem & Biol, Xianning 437100, Peoples R China



[ 2 ] Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China



[ 3 ] Hubei Univ Med, Taihe Hosp, Shiyan 442000, Peoples R China

电子邮件地址:ygh6686@aliyun.com

基金资助致谢

基金资助机构

授权号

Natural Science Foundation of Hubei Provincial Department of Science and Technology

2011CDB08301

Science Research Project of Hubei University of Medicine

2011 CXX03

2609QDJ15

查看基金资助信息

出版商

CHINESE JOURNAL STRUCTURAL CHEMISTRY, FUIJAN INST RES STRUCT MATTER, CHINESE ACAD SCIENCES, FUZHOU, FUJIAN 350002, PEOPLES R CHINA

类别 / 分类

研究方向:Chemistry; Crystallography

Web of Science 类别:Chemistry, Inorganic & Nuclear; Crystallography

文献信息

文献类型:Article

语种:English

入藏号: WOS:000329421300015

ISSN: 0254-5861

期刊信息

Impact Factor (影响因子): Journal Citation Reports®

其他信息

IDS 号: 285UU

Web of Science 核心合集中的 "引用的参考文献": 17

Web of Science 核心合集中的 "被引频次": 0