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LI Yan,TANG He-Xin, GAO Hai-Taob, HU Yang-Gen, Synthesis, Crystal Structure and Antitumor
Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo[2,3-d]
pyrimidine-6-carboxylate, ½á ¹¹ »¯ ѧ £¨JIEGOU HUAXUE),Vol. 32, No. 12.
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junren751113(sunshan4379´ú·¢): ½ð±Ò+10 2014-07-19 17:26:33
Synthesis, Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo [2,3-d] pyrimidine-6-carboxylate


×÷Õß:Li, Y (Li Yan)[ 1 ] ; Tang, HX (Tang He-Xin)[ 2,3 ] ; Gao, HT (Gao Hai-Tao)[ 2 ] ; Hu, YG (Hu Yang-Gen)[ 2,3 ]




CHINESE JOURNAL OF STRUCTURAL CHEMISTRY



¾í: 32

ÆÚ: 12

Ò³: 1868-1872

³ö°æÄê: 2013

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The title compound (C21H24N4O4, M-r = 396.44) has been synthesized by the functionalized ethyl 4-chloro-6-methyl-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylates and morpholine. Its structure was confirmed by means of H-1 NMR JR. MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P (1) over bar, a = 7.9919(8), b = 9.9312(1), c = 12.9380(13) angstrom, alpha = 86.987(2), beta = 83.604(2), gamma = 89.641(2)degrees, V = 1019.08(18) angstrom(3), Z = 2, F(000) = 420, D-c = 1.292 g/cm(3), mu = 0.091 mm(-1), R = 0.0602 and wR = 0.1548 for 3943 independent (R-int = 0.0639) and 3414 observed (I > 2 sigma(I)) reflections. Intermolecular N-H center dot center dot center dot O and pi-pi stacking interactions contributed to the stability of the structure. The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines.


¹Ø¼ü´Ê

×÷Õ߹ؼü´Ê:furo[2,3-d]pyrimidine; synthesis; crystal structure; antitumor activity

KeyWords Plus:THYMIDYLATE SYNTHASE; EFFICIENT SYNTHESIS; LUNG-CANCER; INHIBITORS; TARGET


×÷ÕßÐÅÏ¢

ͨѶ×÷ÕßµØÖ·: Hu, YG (ͨѶ×÷Õß)



      

Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China.



µØÖ·:



      

[ 1 ] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem & Biol, Xianning 437100, Peoples R China



      

[ 2 ] Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China



      

[ 3 ] Hubei Univ Med, Taihe Hosp, Shiyan 442000, Peoples R China



µç×ÓÓʼþµØÖ·:ygh6686@aliyun.com


»ù½ð×ÊÖúÖÂл



»ù½ð×ÊÖú»ú¹¹

ÊÚȨºÅ



Natural Science Foundation of Hubei Provincial Department of Science and Technology


2011CDB08301



Science Research Project of Hubei University of Medicine


2011 CXX03

2609QDJ15

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CHINESE JOURNAL STRUCTURAL CHEMISTRY, FUIJAN INST RES STRUCT MATTER, CHINESE ACAD SCIENCES, FUZHOU, FUJIAN 350002, PEOPLES R CHINA


Àà±ð / ·ÖÀà

Ñо¿·½Ïò:Chemistry; Crystallography

Web of Science Àà±ð:Chemistry, Inorganic & Nuclear; Crystallography


ÎÄÏ×ÐÅÏ¢

ÎÄÏ×ÀàÐÍ:Article

ÓïÖÖ:English

Èë²ØºÅ: WOS:000329421300015

ISSN: 0254-5861


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Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®




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IDS ºÅ: 285UU

Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 17

Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
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