|
|
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★
sunshan4379: 检索EPI+1, 感谢应助！ 2014-07-07 18:54:09
junren751113(sunshan4379代发): 金币+10 2014-07-19 17:26:33
Synthesis, Crystal Structure and Antitumor Activities of Ethyl 5-methyl-4-morpholino-2-(3-Methyl-phenylamino)-furo [2,3-d] pyrimidine-6-carboxylate
作者:Li, Y (Li Yan)[ 1 ] ; Tang, HX (Tang He-Xin)[ 2,3 ] ; Gao, HT (Gao Hai-Tao)[ 2 ] ; Hu, YG (Hu Yang-Gen)[ 2,3 ]
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
卷: 32
期: 12
页: 1868-1872
出版年: 2013
查看期刊信息
摘要
The title compound (C21H24N4O4, M-r = 396.44) has been synthesized by the functionalized ethyl 4-chloro-6-methyl-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylates and morpholine. Its structure was confirmed by means of H-1 NMR JR. MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P (1) over bar, a = 7.9919(8), b = 9.9312(1), c = 12.9380(13) angstrom, alpha = 86.987(2), beta = 83.604(2), gamma = 89.641(2)degrees, V = 1019.08(18) angstrom(3), Z = 2, F(000) = 420, D-c = 1.292 g/cm(3), mu = 0.091 mm(-1), R = 0.0602 and wR = 0.1548 for 3943 independent (R-int = 0.0639) and 3414 observed (I > 2 sigma(I)) reflections. Intermolecular N-H center dot center dot center dot O and pi-pi stacking interactions contributed to the stability of the structure. The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines.
关键词
作者关键词:furo[2,3-d]pyrimidine; synthesis; crystal structure; antitumor activity
KeyWords Plus:THYMIDYLATE SYNTHASE; EFFICIENT SYNTHESIS; LUNG-CANCER; INHIBITORS; TARGET
作者信息
通讯作者地址: Hu, YG (通讯作者)
Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China.
地址:
[ 1 ] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem & Biol, Xianning 437100, Peoples R China
[ 2 ] Hubei Univ Med, Inst Synthet Organ & Med Chem, Shiyan 442000, Peoples R China
[ 3 ] Hubei Univ Med, Taihe Hosp, Shiyan 442000, Peoples R China
电子邮件地址:ygh6686@aliyun.com
基金资助致谢
基金资助机构
授权号
Natural Science Foundation of Hubei Provincial Department of Science and Technology
2011CDB08301
Science Research Project of Hubei University of Medicine
2011 CXX03
2609QDJ15
查看基金资助信息
出版商
CHINESE JOURNAL STRUCTURAL CHEMISTRY, FUIJAN INST RES STRUCT MATTER, CHINESE ACAD SCIENCES, FUZHOU, FUJIAN 350002, PEOPLES R CHINA
类别 / 分类
研究方向:Chemistry; Crystallography
Web of Science 类别:Chemistry, Inorganic & Nuclear; Crystallography
文献信息
文献类型:Article
语种:English
入藏号: WOS:000329421300015
ISSN: 0254-5861
期刊信息
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: 285UU
Web of Science 核心合集中的 "引用的参考文献": 17
Web of Science 核心合集中的 "被引频次": 0 |
|
回复此楼