| 查看: 1777 | 回复: 4 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[求助]
有没有人知道detergent-resistant membranes 已有2人参与
|
|||
| 细胞膜上有抗去垢剂区域吗？detergent-resistant membranes，有没有大神懂得给解释一下，抗去垢剂膜和病毒内吞有何联系？因为一篇文章中说病毒的一些非结构蛋白会和抗去垢剂膜相联系，感谢。。。 |
回复此楼» 猜你喜欢
0856材料与化工，270求调剂
已经有3人回复
-
材料化工调剂
已经有11人回复
-
高分子化学与物理调剂
已经有12人回复
-
0805总分292，求调剂
已经有5人回复
-
306分材料调剂
已经有5人回复
-
化工299分求调剂 一志愿985落榜
已经有5人回复
-
材料学硕318求调剂
已经有11人回复
-
0856化工专硕求调剂
已经有12人回复
-
265分求调剂不调专业和学校有行学上就
已经有7人回复
-
298求调剂
已经有6人回复
【答案】应助回帖
|
History • 80’s Order (package) and disorder phases in diff. parts of the PM. • 90’s Analysis of membrane fractions by the use of mild detergents. The concept of Detergent Resistant Membranes (DRM) born. In this technique non-solubilized fraction of the PM extracts by mild detergent (triton X-100 at 4ºC –artifact conditions-) + sucrose gradient • 2000’s New microscopy techniques: FRET, STED, FRAP… To understand the dynamic of the assembly of sterol, sphingolipds and proteins in living cells (real conditions). Membrane domain definition: Lateral compartment (PM plane) with composition, structure and biological function diff. from the surrounding membrane. Regardless size, stability and mechanism of formation. Why DRMs/DIMs (detergent insoluble microdomains) are not lipid rafts??? • 4ºC is not a real condition for the behavior of the PM. • Quantitative bias due the ratio concentration of detergent:prot. /detergent:lipids Definition by consensus 2006: “Membrane rafts are small (10-200nm), heterogeneous highly dynamic, sterol and sphingolipid-enriched domains that compartmentalized cellular process” What is new here: No: detergent resistant, lipid term, or PM (E.g. membrane of mitochondria), small (need of superesolution techniques). |
3楼2014-06-12 19:20:22
2楼2014-06-12 19:16:49
4楼2019-06-04 12:17:08
5楼2019-06-04 12:21:45
10