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2Â¥2014-06-12 19:16:49
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History • 80¡¯s Order (package) and disorder phases in diff. parts of the PM. • 90¡¯s Analysis of membrane fractions by the use of mild detergents. The concept of Detergent Resistant Membranes (DRM) born. In this technique non-solubilized fraction of the PM extracts by mild detergent (triton X-100 at 4ºC ¨Cartifact conditions-) + sucrose gradient • 2000¡¯s New microscopy techniques: FRET, STED, FRAP¡ To understand the dynamic of the assembly of sterol, sphingolipds and proteins in living cells (real conditions). Membrane domain definition: Lateral compartment (PM plane) with composition, structure and biological function diff. from the surrounding membrane. Regardless size, stability and mechanism of formation. Why DRMs/DIMs (detergent insoluble microdomains) are not lipid rafts??? • 4ºC is not a real condition for the behavior of the PM. • Quantitative bias due the ratio concentration of detergent:prot. /detergent:lipids Definition by consensus 2006: ¡°Membrane rafts are small (10-200nm), heterogeneous highly dynamic, sterol and sphingolipid-enriched domains that compartmentalized cellular process¡± What is new here: No: detergent resistant, lipid term, or PM (E.g. membrane of mitochondria), small (need of superesolution techniques). |
3Â¥2014-06-12 19:20:22
carol21
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4Â¥2019-06-04 12:17:08
carol21
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5Â¥2019-06-04 12:21:45













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