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Cui BC1, Yoon I2, Li JZ3, Lee WK4, Shim YK5.
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Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.
ÆÚ¿¯Ãû,Äê·Ý,¾í(ÆÚ),ÆðÖ¹Ò³Âë:
Int J Mol Sci. 2014 May 8;15(5):8091-105. doi: 10.3390/ijms15058091.
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Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.
×÷Õß:Cui, Bing Cun; Yoon, Il; Li, Jia Zhu; Lee, Woo Kyoung; Shim, Young Key
International journal of molecular sciences
¾í:15 ÆÚ:5 Ò³:8091-105
DOI:10.3390/ijms15058091
³ö°æÄê:2014 May 08
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A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers.
×÷ÕßÐÅÏ¢
µØÖ·:College of Medicine, Hubei Polytechnic University, Huangshi 435003, China. cuibc928@hotmail.com.
ÎÄÏ×ÐÅÏ¢
ÎÄÏ×ÀàÐÍ:Journal Article
ÓïÖÖ:English
PubMed ID:24815070
NLM Ψһ ID:101092791
´´½¨ÈÕÆÚ: 12 May 2014         
µç×Ó³ö°æ:08 May 2014
¹ú¼Ò/µØÇø: Switzerland
ISSN:1422-0067
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Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®
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·ÖÖ÷Ìâ×Ó¿â:Index Medicus
״̬:In-Data-Review
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