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ÊéÃû Cell Death
×÷ÕßGerry Melino
MRC Toxicology Unit, University of Leicester, Leicester, UK
David Vaux
La Trobe University, Victoria, Australia
Ò³Êý 318
³ö°æÉç wiley
ISBN: 978-0-470-71573-4
Ŀ¼Contents
Contributors vii
Preface xi
The Siren¡¯s Song: This Death That Makes Life Live 1
Gerry Melino, Richard A Knight and Jean Claude
Ameisen
The Origin and Evolution of Programmed Cell
Death 13
Jean Claude Ameisen
Cell Death in C. elegans 21
Ataman Sendoel and Michael O Hengartner
Caspases and Cell Death 30
Lorraine D Hernandez, Caroline Houde, Maarten
Hoek, Brent Butts, DonaldWNicholson and Huseyin
Mehmet
The Apoptosome: The Executioner of
Mitochondria-mediated Apoptosis 37
Elisabetta Ferraro and Francesco Cecconi
Caspases, Substrates and Sequential Activation 50
John G Walsh and Seamus J Martin
Dismantling the Apoptotic Cell 60
Paula Deming and Sally Kornbluth
The BCL-2 Family Proteins ¨C Key Regulators and
Effectors of Apoptosis 69
David L Vaux
BH3-only Proteins 75
Lina Happo, Andreas Strasser and Clare L Scott
Mitochondrial Outer Membrane Permeabilization 90
Melissa J Parsons and Douglas R Green
Mitochondria Fusion and Fission 97
Giovanni Benard, Guihong Peng and Mariusz
Karbowski
Death Receptors 110
Peter H Krammer and Inna N Lavrik
Death Receptors at the Molecular Level:
Therapeutic Implications 117
Marion MacFarlane
Death Receptor-induced Necroptosis 127
Wim Declercq, Franky Van Herreweghe,
Tom Vanden Berghe and Peter Vandenabeele
Inhibitor of Apoptosis (IAP) and BIR-containing
Proteins 138
David L Vaux
Structures, Domains and Functions in Cell Death
(DD, DED, CARD, PYD) 147
Hao Wu and Yu-Chih Lo
Structure and Function of IAP and Bcl-2 Proteins 156
Mark G Hinds, Peter D Mace and Catherine L Day
Engulfment of Apoptotic Cells and its Physiological
Roles 165
Rikinari Hanayama, Masanori Miyanishi, Hiroshi
Yamaguchi, Jun Suzuki and Shigekazu Nagata
Autophagy 175
Marı¡äa Isabel Colombo and Hans-Uwe Simon
Autophagy in Nonmammalian Systems 189
Jahda H Hill and Eric H Baehrecke
Apoptosis: Regulatory Genes and Disease 197
James E Vince and John Silke
Caspases in Inflammation and Immunity 212
Philippe M LeBlanc and Maya Saleh
Immunity, Granzymes and Cell Killing 223
Nigel J Waterhouse, Olivia Susanto, KarinASedelies
and Joseph A Trapani
P53 and Cell Death 230
Kamil Wolyniec, Sue Haupt and Ygal Haupt
Cornification of the Skin: A Non-apoptotic¡ï¡ï¡ï¡ï¡ï¡ï¡ï2014Êé¼®³¬¼¶ÌûÒ»ÆßÁù¡¶Ï¸°ûËÀÍö¡·²ÊÉ«Ó¢ÎĸßÇåÀ´Ï®
Gerry Melino, David Vaux-Cell Death (Encyclopedia of Life Sciences) (2010).jpg


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