小女子以前了解过利用巯基二硫键交换反应生成二硫键用于药物载体。反应底物为PEG、PCL等高分子，为什么反应需要酸催化啊？
我查资料说是thiol–disulfide exchange is inhibited at low pH (typically, below 8) where the protonated thiol form is favored relative to the deprotonated thiolate form. (The pKa of a typical thiol group is roughly 8.3, but can vary due to its environment.) 这不说是需要碱性条件吗？
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