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ÖÐÎÄ£ºÆÕÀ­ÌØÃ¹ËØÊÇÒ»ÖÖ´ó»·ÄÚõ¥À࿹ÉúËØ¡£±¾ÎĽ¨Á¢ÁËÒ»ÖÖÀûÓÃA½«ÂóµÏÃ¹ËØ×ª»¯ÎªÆÕÀ­ÌØÃ¹Ëصķ½·¨£¬·¢½Í²úÁ¿´ïµ½5.528g/L¡£Í¨¹ýµ÷½ÚpH½øÐз´¸´³ÁµíÈܽâ´ÖÌáÈ¡ÓëODS·´Ïà²ãÎö·ÖÀ뾫ÌáÈ¡Ïà½áºÏµÄ·½·¨¶Ô·¢½ÍÒºÖÐµÄÆÕÀ­ÌØÃ¹ËØA1½øÐзÖÀë´¿»¯£¬µÃµ½´¿¶ÈΪ97.74%µÄ´¿Æ·£¬¶ÔËùµÃ´¿Æ·½øÐÐÁËMALDI-TOF-MSºÍNMR¼ì²â£¬È·¶¨ÁËËùµÃÎïÖÊΪÆÕÀ­ÌØÃ¹ËØ¡£¶ÔÌá´¿ºóµÄÆÕÀ­ÌØÃ¹ËØA1½øÐÐÁËÌåÍâҩЧÊÔÑ飬ÑéÖ¤ÁËÆÕÀ­ÌØÃ¹ËضÔStaphyloccocus aureu¡¢Streptococcus pneumoniaeºÍSeptic StreptococcusºÍPorcine Actinobacillus pleuropneumoniae¶¼¾ßÓнϺõÄÒ©ÎïÃô¸ÐÐÔ¡£
Ó¢ÎÄ£ºPlatenomycin is a macrolide antibiotic. The process for producing antibiotic composition Platenomycin by bioconversion of Midecamycin by A was investigated. The highest yield of Platenomycin was 5.654g/L. Recovering the antibiotic from the fermentation broth by adjusting the pH, and purifying the crude residue to 97.74%. The purified compound was identified as Platenomycin by MALDI-TOF-MS and NMR. Results demonstrated that this macrolide is active against Staphyloccocus aureu¡¢Streptococcus pneumoniae¡¢Septic Streptococcus and Porcine Actinobacillus pleuropneumoniae.
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icebergwu: ½ð±Ò+12, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2014-03-01 11:19:27
Platenomycin is a kind of macrolide antibiotic. By using A,we established a method to turn  Midecamycin  into  Pratt neomycin ,with which fermentation production    come to  5.528g / L.  Through adjusting the PH  to repeatedly precipitation and dissolve the crude extract  combined  with  ODS reversed phase chromatography method ,the Pratt ADM A1 in the fermentation broth were isolated and purified.The product is of  97.74%  purity   and identified of Pratt neomycin by MALDI-TOF-MS and NMR detection. In vitro efficacy trials conducted   of  the purified Pratt ADM  A1  verified  that Pratt ADM  has  better drug sensitivity on Staphyloccocus aureu,Streptococcus pneumoniae,Septic Streptococcus and Porcine Actinobacillus pleuropneumoniae.
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3Â¥2014-02-28 22:47:06
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xianghuayu

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RXMCDM: ½ð±Ò+1, ¶àлӦÖú£¡ 2014-02-28 22:48:32
icebergwu: ½ð±Ò+8, ·­ÒëEPI+1 2014-03-01 11:19:18
The preparation of Platenomycin,  a macrolide antibiotic, through bioconversion of Midecamycin using A was investigated, giving the highest yield of Platenomycin at 5.654g/L. A purity of 97.74% was achieved after recovering the antibiotic from the fermentation broth through adjusting pH, and multiple purification of the crude residue. The final compound was verified as Platenomycin by MALDI-TOF-MS and NMR. Clinical results demonstrate that the macrolide is active against Staphyloccocus aureu, Streptococcus pneumoniae, Septic Streptococcus, and Porcine Actinobacillus pleuropneumoniae.
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2Â¥2014-02-28 22:10:20
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icebergwu

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2Â¥: Originally posted by xianghuayu at 2014-02-28 22:10:20
The preparation of Platenomycin,  a macrolide antibiotic, through bioconversion of Midecamycin using A was investigated, giving the highest yield of Platenomycin at 5.654g/L. A purity of 97.74% was a ...

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4Â¥2014-03-01 11:19:48
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icebergwu

ľ³æÖ®Íõ (ÎÄѧ̩¶·)

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3Â¥: Originally posted by RXMCDM at 2014-02-28 22:47:06
Platenomycin is a kind of macrolide antibiotic. By using A,we established a method to turn  Midecamycin  into  Pratt neomycin ,with which fermentation production    come to  5.528g / L.  Through adju ...

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5Â¥2014-03-01 11:19:56
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