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求助-汤森路透药物报告 已有1人参与
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求助Arbidol的汤森路透药物报告，谢谢！ [ Last edited by 审雨堂88 on 2014-2-27 at 09:55 ] |
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【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
审雨堂88: 金币+5, ★有帮助, 谢谢 2014-02-27 16:02:09
感谢参与，应助指数 +1
审雨堂88: 金币+5, ★有帮助, 谢谢 2014-02-27 16:02:09
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Accession No: 18965 Main Details Drug Name World Status Pharma Status Arbidol Launched Fully Launched Latest Change Updated On By Latest Change 3 Jun 1994 UN Minor change Company Status Data Originator Country Development Stage Non-industrial source Unspecified Launched Activity Data Therapy Description Code Therapy Status Immunostimulant, other I1Z Launched Antiviral, other J5Z Launched Pharmacology Description Code Immunostimulant IM+ Therapy Code Pharmacology Code I1Z J5Z IM+ IM+ Route of Administration Route of Administration Code Alimentary, po A-PO Indication Indication Status Infection, influenza virus Launched Target Data Target Name LocusLink/Entrez Gene ID Unspecified Unspecified -------------------------------------------------------------------------------- Target Family Group(s) Receptor > Cytokine receptor > Class II Chemical Data Origin of Material Code Description CH-SY Chemical, synthetic CAS Registry Number Rotatable Bonds Molecular Formula 131707-23-8 9 C22H26BrClN2O3S Hydrogen Bond Acceptors Hydrogen Bond Donors AlogP Molecular Weight 6 1 4.50 477.42 Chemical Name 1H-indole-3-carboxylic acid, 6-bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-, ethylester, monohydrochloride [CAS] Structure New Chemical Entity Yes Patent Data Country Number Priority Country Priority Date WO 9008135 WO 12 January 1989 Country Data Country Name Country Status Year Launched Licensing Op. Argentina - Yes Australia - Yes Austria - Yes Belgium - Yes Brazil - Yes Canada - Yes Chile - Yes China - Yes Colombia - Yes Denmark - Yes Finland - Yes France - Yes Germany - Yes Greece - Yes Hong Kong - Yes India - Yes Ireland - Yes Israel - Yes Italy - Yes Japan - Yes Luxembourg - Yes Malaysia - Yes Mexico - Yes Netherlands - Yes New Zealand - Yes Norway - Yes Peru - Yes Philippines - Yes Portugal - Yes Russian Federation Launched Yes South Africa - Yes South Korea - Yes Spain - Yes Sweden - Yes Switzerland - Yes Thailand - Yes Turkey - Yes UK - Yes USA - Yes Venezuela - Yes Major Events Event Date Act/Est Event Details 15 Oct 1992 Est New Product in Pharmaprojects 15 Oct 1992 Est Licensing Opportunities Worldwide Ratings Novelty Market Size Speed Total Established Strategy (2) US$ 0-500 million (1) Not available (0) Not available Detailed Information Arbidol is an interferon-inducer, developed by Dr I S Nikolaeva of the Centre for Chemistry of Drugs, VNIKhFI, Zubovskay Street 7, Moscow 119517, Russia, as a therapeutic and prophylactic for influenza A and B and other respiratory viral infections (Personal communication, Sep 1992). Marketing It is launched in Russia for therapeutic use in influenza A and B. Clinical Phase III In 2000 influenza patients, Arbidol 0.2g po tid or qid for 3 days reduced the duration of fever, catarrhal syndrome and overall disease, and prevented the development of post-influenzal complications. A prophylactic effect was achieved by 100mg twice/wk. It had an efficacy index of 5.16 (cf 1.0 for ramantadine) (18th Int Cong Chemother (Stockholm), 1993, Abs 190; Personal communication, Jun 1993). In 12 volunteers, 300mg/kg po produced interferon titres of 160IU/ml 24hr after administration (4th BICON (Prague), 1992, Abs 155). Preclinical In cell culture, it inhibited the plaque-forming activity of influenza virus without affecting its haemagglutinating activity. Licensing Arbidol is available for licensing worldwide (Personal communication, Sep 1992). |
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