Znn3bq.jpeg
²é¿´: 1935  |  »Ø¸´: 8
µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû

xwzeng2006

Òø³æ (ÖøÃûдÊÖ)

[ÇóÖú] ¹ØÓÚÒ¶Ëá»î»¯·´Ó¦ÊÇ·ñ¼ÓÈëÈýÒÒ°·

Briefly, to a solution of folic acid (1.0 g, 2.27 mmol) in 40 ml of dry DMSO was
added triethylamine (0.5 ml), N-hydroxysuccinimide (0.52 g, 5.00 mmol), and
dicyclohexylcarbodiimide (0.50 g, 2.50 mmol). The mixture was stirred at room temperature in
the dark for 24 h. The byproduct, dicyclohexylurea, was filtered off, and 200 ml of
acetone/diethyl ether (1:3, v/v) was added to precipitate the product.

Ò¶Ëá»î»¯²ÉÓÃDCC/NHS£¬ÔÚDMSOÖз´Ó¦£¬ÎÒ¿´ÓÐЩÎÄÏ×ÖмÓÈëÉÙÁ¿ÈýÒÒ°·£¬ÓÐЩûÓмӣ¬ÇëÎÊ´ó¼ÒƽʱÔõô×öÄØ£¿¼Ó²»¼ÓÈýÒÒ°·£¬Èç¹û¼ÓÈýÒÒ°·£¬ÄÇÄ¿µÄÊÇÊ²Ã´ÄØ£¿
»Ø¸´´ËÂ¥
ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

xwzeng2006

Òø³æ (ÖøÃûдÊÖ)

ÒýÓûØÌû:
3Â¥: Originally posted by huquan0_0 at 2013-05-07 11:24:44
Èç¹û¿ÉÒÔ²»¼Ó  ¾Í²»Òª¼Ó   ¶àÒ»¸ö¶«Î÷ ¶àһЩÎÊÌâ

ÎÒ×öµÄ»°ÊDz»¼ÓµÄ

Äã×ö¹ý£¬²»¼ÓЧ¹ûÒ»ÑùÂð£¿
5Â¥2013-05-07 14:14:55
ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
²é¿´È«²¿ 9 ¸ö»Ø´ð

huquan0_0

¾èÖú¹ó±ö (ÕýʽдÊÖ)

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¡ï
¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
fool_proof: ½ð±Ò+1, »¶Ó­³£À´ÉúÎï²ÄÁϰæÓ¦Öú½»Á÷ 2013-05-07 17:45:29
Èç¹û¿ÉÒÔ²»¼Ó  ¾Í²»Òª¼Ó   ¶àÒ»¸ö¶«Î÷ ¶àһЩÎÊÌâ

ÎÒ×öµÄ»°ÊDz»¼ÓµÄ
º£Äɰٴ¨ÓÐÈÝÄË´ó£»×ÔÇ¿²»Ï¢Ö¹ÓÚÖÁÉÆ¡£
3Â¥2013-05-07 11:24:44
ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

xwzeng2006

Òø³æ (ÖøÃûдÊÖ)

Äã×ö¹ý£¬²»¼ÓЧ¹ûÒ»ÑùÂð£¿
4Â¥2013-05-07 14:14:41
ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

aircraftvip

ר¼Ò¹ËÎÊ (ÕýʽдÊÖ)

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
xwzeng2006: ½ð±Ò+5, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸, ÀÏÐÖ£¬ÄãÌ«À÷º¦ÁË£¡ 2013-05-07 21:19:14
fool_proof: ½ð±Ò+1, ר¼Ò¿¼ºË, »¶Ó­³£À´ÉúÎï²ÄÁϰæÓ¦Öú½»Á÷ 2013-05-07 21:51:48
¹ØÓÚNHS-Folic acidµÄºÏ³É·½°¸£¬Äã˵µÄÕâÆªÎÄÕÂ1²¢Ã»ÓÐÒýÓÃÔ­ÎÄÏס£
ÎÄÕÂ1£ºTumor site-specific silencing of NF-¦ÊB p65 by targeted hollow gold nanospheres-mediated photothermal transfection  Cancer Res. 2010 April 15; 70(8): 3177¨C3188.

Ö»ÊÇÔÚ¸½¼ÓÐÅÏ¢ÀïÃæÒýÓÃÁËÎÄÕÂ2£º Van Steenis, J.H. et al. Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes. J Control Release 87, 167-176 (2003).

¶øÎÄÕÂ2È´ÒýÓÃÁËÁíһƪÎÄÏ×3£ºReceptor-targeted gene delivery via folate-conjugated polyethylenimine.AAPS PharmSci. 1999;1(4):E19. ¶øÎÄÏ×3ÀïÃæ²¢Ã»ÓÐʹÓÃTEA¡£
http://www.torna.do/a/jRbQMVxfyx ... ci_www.torna.do.pdf

½áÂÛÊǺܶàÎÄÏ×Ö»Óвο¼¼ÛÖµ£¬µ«²»¿Éä´Ó¡£Èç¹û·ÇÒª¸ã¸öÃ÷°×£¬×ö¸ö¶ÔÕÕʵÑ飬һ¹ø¼ÓTEA£¬Ò»¹ø²»¼Ó£¬½á¹û×ÔÓзÖÏþ¡£
¸ñÎïÖÂÖª£¬ÖªÐкÏÒ»
6Â¥2013-05-07 18:04:43
ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] Ò»Ö¾Ô¸211µç×ÓÐÅÏ¢347Çóµ÷¼Á +3 554916 2026-04-03 4/200 2026-04-09 22:24 by 554916
[¿¼ÑÐ] Ò»Ö¾Ô¸0703»¯Ñ§ÕÐ61×îÖÕÅÅÃû62»¯Ñ§Çóµ÷¼Á +16 ÕÐ61ÅÅÃû62 2026-04-07 19/950 2026-04-09 20:44 by zhouxiaoyu
[¿¼ÑÐ] 266Çóµ÷¼Á +25 ÑôÑôÍÛÈû 2026-04-07 25/1250 2026-04-09 20:32 by onlyÖÜ
[¿¼ÑÐ] 316Çóµ÷¼Á +3 Ïë¶ÁÑо¿Éú( ?¡ß 2026-04-07 3/150 2026-04-09 17:31 by wp06
[¿¼ÑÐ] 275Çóµ÷¼Á +5 1624447980 2026-04-08 6/300 2026-04-09 17:25 by wp06
[¿¼ÑÐ] 270Çóµ÷¼Á +3 031127 2026-04-06 4/200 2026-04-08 21:00 by ÄæË®³Ë·ç
[¿¼ÑÐ] 285Çóµ÷¼Á +12 AZMK 2026-04-05 18/900 2026-04-08 20:43 by ÄæË®³Ë·ç
[¿¼ÑÐ] 301Çóµ÷¼Á +18 121. 2026-04-04 18/900 2026-04-07 17:49 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 328Çóµ÷¼Á +4 ghhh88888 2026-04-06 5/250 2026-04-07 14:45 by ghhh88888
[¿¼ÑÐ] 085405Èí¼þ¹¤³Ì301·ÖÇóµ÷¼Á£¬×¨Ë¶¿É¿çרҵ£¬ËÄÁù¼¶Òѹý +3 ¾²¾²ÏëÏë 2026-04-05 3/150 2026-04-06 15:23 by nepu_uu
[¿¼ÑÐ] Ò»Ö¾Ô¸ÄϺ½£¬ÊýһӢһѧ˶317Çóµ÷¼Á£¡£¡ +6 Acaciad 2026-04-04 6/300 2026-04-06 12:13 by ¿¼ÑÐѧУÕеãÈË
[¿¼ÑÐ] Ò»Ö¾Ô¸Î÷±±Å©ÁÖÐóÄÁר˶336·ÖÇóµ÷¼Á +3 5ourr 2026-04-03 3/150 2026-04-05 10:40 by JOKER0401
[¿¼ÑÐ] 295Çóµ÷¼Á +4 AÄãºÃÑо¿Éú 2026-04-04 5/250 2026-04-04 22:46 by yu221
[¿¼ÑÐ] Ò»Ö¾Ô¸ÄÏÅ©090401£¬268£¬Çóµ÷¼Á +5 һľÄñÈ» 2026-04-04 5/250 2026-04-04 17:07 by babysonlkd
[¿¼ÑÐ] 357Çóµ÷¼Á +13 1050389037 2026-04-03 13/650 2026-04-03 22:27 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] Ò»Ö¾Ô¸ÖйúʯÓÍ´óѧ»¯Ñ§¹¤³Ì323·ÖÇóµ÷¼Á +4 »¯¹¤×¨Ë¶323·Ö 2026-04-03 6/300 2026-04-03 22:12 by dongzh2009
[¿¼ÑÐ] 281Çóµ÷¼Á +10 aaawhy 2026-04-03 10/500 2026-04-03 21:42 by lbsjt
[¿¼ÑÐ] 335Çóµ÷¼Á +7 ÉòÇåÁ§ 2026-04-03 7/350 2026-04-03 18:55 by lijunpoly
[¿¼ÑÐ] 289-Çóµ÷¼Á +4 ÕâÀïÊÇ_ 2026-04-03 4/200 2026-04-03 14:23 by 1753564080
[¿¼ÑÐ] 320Çóµ÷¼Á +3 ũҵ¹¤³ÌÓëÐÅÏ¢¼ 2026-04-03 3/150 2026-04-03 11:40 by ÍÁľ˶ʿÕÐÉú
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û