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Briefly, to a solution of folic acid (1.0 g, 2.27 mmol) in 40 ml of dry DMSO was added triethylamine (0.5 ml), N-hydroxysuccinimide (0.52 g, 5.00 mmol), and dicyclohexylcarbodiimide (0.50 g, 2.50 mmol). The mixture was stirred at room temperature in the dark for 24 h. The byproduct, dicyclohexylurea, was filtered off, and 200 ml of acetone/diethyl ether (1:3, v/v) was added to precipitate the product. Ò¶Ëá»î»¯²ÉÓÃDCC/NHS£¬ÔÚDMSOÖз´Ó¦£¬ÎÒ¿´ÓÐЩÎÄÏ×ÖмÓÈëÉÙÁ¿ÈýÒÒ°·£¬ÓÐЩûÓмӣ¬ÇëÎÊ´ó¼ÒƽʱÔõô×öÄØ£¿¼Ó²»¼ÓÈýÒÒ°·£¬Èç¹û¼ÓÈýÒÒ°·£¬ÄÇÄ¿µÄÊÇÊ²Ã´ÄØ£¿ |
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