24小时热门版块排行榜    

查看: 1750  |  回复: 9
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

梦尘逸

新虫 (初入文坛)

[求助] 求助,这样说文章能不能被接受?

本人前一段时间在international immunopharmacology上头了一篇文章,影响因子不高2.3吧,审稿意见回来了,有一个审稿人就提了3个问题,还都是小问题,基本没什么事,不过另一个审稿人却是这么说的
Reviewer #2: The authors of this study claimed that synergistic effects of blocking IL-1beta and IL-17A could suppress the rheumatoid development in CIA mouse model.  Blocking of IL-1 and IL-17signaling pathway have been shown playing function in delaying or preventing the development of rheumatoid arthritis. In this study, the authors did not point out any new information in addition to well-documented. Detailed mechanism on how those two molecules play a synergistic effect is more favored.
And there are also several other questions.
1. The whole experiment was done in DBA mice, why humanized antibodies were used? Please justify the structural similarity of both human and murine IL-1 beta and IL-17A as well as the crossreactivities of those blocking antibody.
2. In 3.4 and 3.5, as author stated, it should be ex vivo experiment but not in vitro.

求助大神们这种意见应该怎么办呢,问题严不严重啊?我最好怎么回答他,已经困扰好久了
回复此楼
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

梦尘逸

新虫 (初入文坛)

引用回帖:
6楼: Originally posted by nuaawq at 2012-11-19 21:12:32
认真去改的话 希望很大 啊。。。。。。

正在改ing
8楼2012-11-20 11:28:54
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 10 个回答

梦尘逸

新虫 (初入文坛)

自己顶下,跪求意见
2楼2012-11-19 16:29:25
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

nono2009

超级版主 (文学泰斗)

No gains, no pains.

优秀区长优秀区长优秀区长优秀区长优秀版主

【答案】应助回帖

感谢参与,应助指数 +1
编辑让你改,说明希望很大。好好改,不能改也好好解释
3楼2012-11-19 19:42:59
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

xianjin1985

铁杆木虫 (著名写手)

【答案】应助回帖

感谢参与,应助指数 +1
感觉应该会有机会被接受,只要认真去改,并且对第二个审稿人的意见适当接受,看自己怎么改了吧
4楼2012-11-19 20:15:38
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[考研] 一志愿吉林大学材料学硕321求调剂 +6 Ymlll 2026-03-18 9/450 2026-03-19 10:28 by 星空星月
[考研] 0817调剂 +3 没有答案_ 2026-03-14 3/150 2026-03-19 09:51 by Xu de nuo
[考研] 274求调剂 +6 S.H1 2026-03-18 6/300 2026-03-19 09:34 by 花店相见
[考研] 一志愿华中科技大学,080502,354分求调剂 +4 守候夕阳CF 2026-03-18 4/200 2026-03-18 22:16 by li123456789.
[考研] 085600材料与化工 +5 安全上岸! 2026-03-16 5/250 2026-03-18 15:33 by cmz0325
[考研] 085601专硕,总分342求调剂,地区不限 +5 share_joy 2026-03-16 5/250 2026-03-18 14:48 by haxia
[考研] 299求调剂 +5 △小透明* 2026-03-17 5/250 2026-03-18 11:49 by 尽舜尧1
[考研] 303求调剂 +4 睿08 2026-03-17 6/300 2026-03-18 11:01 by Iveryant
[考研] 0703化学调剂 +3 妮妮ninicgb 2026-03-17 3/150 2026-03-18 10:29 by macy2011
[考研] 材料,纺织,生物(0856、0710),化学招生啦 +3 Eember. 2026-03-17 9/450 2026-03-18 10:28 by Eember.
[考研] 0703化学336分求调剂 +6 zbzihdhd 2026-03-15 7/350 2026-03-18 09:53 by zhukairuo
[考研] 有没有道铁/土木的想调剂南林,给自己招师弟中~ +3 TqlXswl 2026-03-16 7/350 2026-03-17 15:23 by TqlXswl
[考研] 290求调剂 +6 孔志浩 2026-03-12 11/550 2026-03-17 14:41 by 周舟舟77
[考研] 278求调剂 +3 Yy7400 2026-03-13 3/150 2026-03-17 08:24 by laoshidan
[基金申请] 今年的国基金是打分制吗? 50+3 zhanghaozhu 2026-03-14 3/150 2026-03-16 17:07 by 北京莱茵润色
[考研] 070300化学学硕求调剂 +6 太想进步了0608 2026-03-16 6/300 2026-03-16 16:13 by kykm678
[考研] 289求调剂 +4 这么名字咋样 2026-03-14 6/300 2026-03-14 18:58 by userper
[考研] 330求调剂 +3 ?酱给调剂跪了 2026-03-13 3/150 2026-03-14 10:13 by JourneyLucky
[考研] [0860]321分求调剂,ab区皆可 +4 宝贵热 2026-03-13 4/200 2026-03-13 22:01 by 星空星月
[考研] 307求调剂 +5 超级伊昂大王 2026-03-12 5/250 2026-03-13 15:56 by 棒棒球手
信息提示
请填处理意见