Znn3bq.jpeg
²é¿´: 1835  |  »Ø¸´: 9
µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû

Ãγ¾ÒÝ

гæ (³õÈëÎÄ̳)

[ÇóÖú] ÇóÖú£¬ÕâÑù˵ÎÄÕÂÄܲ»Äܱ»½ÓÊÜ£¿

±¾ÈËǰһ¶Îʱ¼äÔÚinternational immunopharmacologyÉÏÍ·ÁËһƪÎÄÕ£¬Ó°ÏìÒò×Ó²»¸ß2.3°É£¬Éó¸åÒâ¼û»ØÀ´ÁË£¬ÓÐÒ»¸öÉó¸åÈ˾ÍÌáÁË3¸öÎÊÌ⣬»¹¶¼ÊÇСÎÊÌ⣬»ù±¾Ã»Ê²Ã´Ê£¬²»¹ýÁíÒ»¸öÉó¸åÈËÈ´ÊÇÕâô˵µÄ
Reviewer #2: The authors of this study claimed that synergistic effects of blocking IL-1beta and IL-17A could suppress the rheumatoid development in CIA mouse model.  Blocking of IL-1 and IL-17signaling pathway have been shown playing function in delaying or preventing the development of rheumatoid arthritis. In this study, the authors did not point out any new information in addition to well-documented. Detailed mechanism on how those two molecules play a synergistic effect is more favored.
And there are also several other questions.
1. The whole experiment was done in DBA mice, why humanized antibodies were used? Please justify the structural similarity of both human and murine IL-1 beta and IL-17A as well as the crossreactivities of those blocking antibody.
2. In 3.4 and 3.5, as author stated, it should be ex vivo experiment but not in vitro.

ÇóÖú´óÉñÃÇÕâÖÖÒâ¼ûÓ¦¸ÃÔõô°ìÄØ£¬ÎÊÌâÑϲ»ÑÏÖØ°¡£¿ÎÒ×îºÃÔõô»Ø´ðËû£¬ÒѾ­À§ÈźþÃÁË
»Ø¸´´ËÂ¥

» ÊÕ¼±¾ÌûµÄÌÔÌûר¼­ÍƼö

decision in progress

» ²ÂÄãϲ»¶

» ±¾Ö÷ÌâÏà¹Ø¼ÛÖµÌùÍÆ¼ö£¬¶ÔÄúͬÑùÓаïÖú:

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

nono2009

³¬¼¶°æÖ÷ (ÎÄѧ̩¶·)

No gains, no pains.

ÓÅÐãÇø³¤ÓÅÐãÇø³¤ÓÅÐãÇø³¤ÓÅÐãÇø³¤ÓÅÐã°æÖ÷

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
±à¼­ÈÃÄã¸Ä£¬ËµÃ÷Ï£ÍûºÜ´ó¡£ºÃºÃ¸Ä£¬²»ÄܸÄÒ²ºÃºÃ½âÊÍ
3Â¥2012-11-19 19:42:59
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
²é¿´È«²¿ 10 ¸ö»Ø´ð

Ãγ¾ÒÝ

гæ (³õÈëÎÄ̳)

×Ô¼º¶¥Ï£¬¹òÇóÒâ¼û
2Â¥2012-11-19 16:29:25
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

xianjin1985

Ìú¸Ëľ³æ (ÖøÃûдÊÖ)

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
¸Ð¾õÓ¦¸Ã»áÓлú»á±»½ÓÊÜ£¬Ö»ÒªÈÏÕæÈ¥¸Ä£¬²¢ÇÒ¶ÔµÚ¶þ¸öÉó¸åÈ˵ÄÒâ¼ûÊʵ±½ÓÊÜ£¬¿´×Ô¼ºÔõô¸ÄÁ˰É
4Â¥2012-11-19 20:15:38
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

visitor958

ÖÁ×ðľ³æ (ÎÄ̳¾«Ó¢)

IEEEÔÓÖ¾Óë»áÒéר¼Ò

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
Õâ¸öÒ»¶¨ÒªÈÏÕæ¿ÍÆøµÄ»Ø¸´£¬Ä㾡Á¿°É£¬Éó¸åÈËÓеļá³Ö£¬ÓеĿ´µ½±à¼­Ã»Óоܣ¬¾ÍËãÁË£¨¾¡Á¿²»Õұ༭Âé·³£©¡£¡£¡£
5Â¥2012-11-19 20:43:28
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ¸´ÊÔµ÷¼Á£¬Ò»Ö¾Ô¸Ö£ÖÝ´óѧ²ÄÁÏÓ뻯¹¤289·Ö +14 ˶ÐǸ° 2026-04-08 14/700 2026-04-08 23:59 by GouQ
[¿¼ÑÐ] 266µ÷¼Á +8 daya sun 2026-04-07 9/450 2026-04-08 20:27 by yutian743
[¿¼ÑÐ] Ò»Ö¾Ô¸µç×ӿƼ¼´óѧ085600²ÄÁÏÓ뻯¹¤ 329·ÖÇóµ÷¼Á +11 Naiko 2026-04-04 11/550 2026-04-08 14:00 by wutongshun
[¿¼ÑÐ] Çóµ÷¼Á²ÄÁÏ¿ÆÑ§Ó빤³ÌÒ»Ö¾Ô¸985³õÊÔ365·Ö +3 ²Ä»¯Àî¿É 2026-04-08 3/150 2026-04-08 11:46 by zzucheup
[¿¼ÑÐ] Ò»Ö¾Ô¸Ö£ÖÝ´óѧ²ÄÁÏÓ뻯¹¤085600£¬Çóµ÷¼Á +34 ³ÔµÄ²»ÉÙ 2026-04-02 34/1700 2026-04-07 20:01 by lrll?l
[¿¼ÑÐ] 085404 293Çóµ÷¼Á +8 ÓÂÔ¶¿â°®314 2026-04-06 9/450 2026-04-07 13:05 by flydream1314
[¿¼ÑÐ] »¯¹¤µ÷¼Á303·Ö£¬¹ýËļ¶ +34 ÆÜÎà´ý·ç 2026-04-02 34/1700 2026-04-07 12:30 by 1018329917
[¿¼ÑÐ] 26×ÔÈ»µØÀíѧ303·ÖÇóµ÷¼Á +4 Ò»Õ½³É˶°¡°¡°¡° 2026-04-06 9/450 2026-04-06 20:35 by lin-da
[¿¼ÑÐ] 346·ÖµÄÉúÎïÓëÒ½Ò©08600Çóµ÷¼Á +6 ³£ÓêÑôÉϰ¶ 2026-04-05 7/350 2026-04-06 12:36 by lys0704
[¿¼ÑÐ] µ÷¼Á +3 Àî¹ã»ð 2026-04-05 3/150 2026-04-05 18:57 by À¶ÔÆË¼Óê
[¿¼ÑÐ] ¹¤¿Æ08-»úеר˶-Çóµ÷¼Á +3 À×Å··ÉÌß 2026-04-02 3/150 2026-04-05 18:49 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 282Çóµ÷¼Á +7 aaa³µÁ¾ 2026-04-02 11/550 2026-04-05 17:24 by yulian1987
[¿¼ÑÐ] 313Çóµ÷¼Á +5 º£ÈÕº£ÈÕ 2026-04-04 5/250 2026-04-05 15:52 by jndximd
[¿¼ÑÐ] ¹¤¿Æ277·ÖÇóµ÷¼Á²ÄÁÏ +8 ÉÏÁËÉÏÁËÉÏŶ 2026-04-05 9/450 2026-04-05 13:05 by wwytracy
[¿¼ÑÐ] 372·Ö²ÄÁÏÓ뻯¹¤£¨085600£©Ò»Ö¾Ô¸ºþÄÏ´óѧÇóµ÷¼Á +3 À¶¼ãƬ 2026-04-03 4/200 2026-04-03 17:58 by Jimmyandyou
[¿¼ÑÐ] 289-Çóµ÷¼Á +4 ÕâÀïÊÇ_ 2026-04-03 4/200 2026-04-03 14:23 by 1753564080
[¿¼ÑÐ] ¹¤¿Æ341·Öµ÷¼Á +3 Âå¶àÂÞ 2026-04-03 3/150 2026-04-03 14:20 by 1753564080
[¿¼ÑÐ] Çó²ÄÁϵ÷¼Á Ò»Ö¾Ô¸Äϲý´óѧ 328·Ö +5 yyy..... 2026-04-03 5/250 2026-04-03 13:46 by °ÙÁéͯ888
[¿¼ÑÐ] 348Çóµ÷¼Á +6 ÎâÑå׿24k 2026-04-02 6/300 2026-04-02 14:07 by ¸øÄãÄã×¢ÒâÐÝÏ¢
[¿¼ÑÐ] 270µ÷¼Á +7 maxjxbsk 2026-04-02 7/350 2026-04-02 09:50 by yulian1987
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û