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Reviewer #2: The authors of this study claimed that synergistic effects of blocking IL-1beta and IL-17A could suppress the rheumatoid development in CIA mouse model.  Blocking of IL-1 and IL-17signaling pathway have been shown playing function in delaying or preventing the development of rheumatoid arthritis. In this study, the authors did not point out any new information in addition to well-documented. Detailed mechanism on how those two molecules play a synergistic effect is more favored.
And there are also several other questions.
1. The whole experiment was done in DBA mice, why humanized antibodies were used? Please justify the structural similarity of both human and murine IL-1 beta and IL-17A as well as the crossreactivities of those blocking antibody.
2. In 3.4 and 3.5, as author stated, it should be ex vivo experiment but not in vitro.

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