24小时热门版块排行榜    

查看: 1742  |  回复: 9
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

梦尘逸

新虫 (初入文坛)

[求助] 求助,这样说文章能不能被接受?

本人前一段时间在international immunopharmacology上头了一篇文章,影响因子不高2.3吧,审稿意见回来了,有一个审稿人就提了3个问题,还都是小问题,基本没什么事,不过另一个审稿人却是这么说的
Reviewer #2: The authors of this study claimed that synergistic effects of blocking IL-1beta and IL-17A could suppress the rheumatoid development in CIA mouse model.  Blocking of IL-1 and IL-17signaling pathway have been shown playing function in delaying or preventing the development of rheumatoid arthritis. In this study, the authors did not point out any new information in addition to well-documented. Detailed mechanism on how those two molecules play a synergistic effect is more favored.
And there are also several other questions.
1. The whole experiment was done in DBA mice, why humanized antibodies were used? Please justify the structural similarity of both human and murine IL-1 beta and IL-17A as well as the crossreactivities of those blocking antibody.
2. In 3.4 and 3.5, as author stated, it should be ex vivo experiment but not in vitro.

求助大神们这种意见应该怎么办呢,问题严不严重啊?我最好怎么回答他,已经困扰好久了
回复此楼
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

nuaawq

至尊木虫 (知名作家)

【答案】应助回帖

感谢参与,应助指数 +1
认真去改的话 希望很大 啊。。。。。。
6楼2012-11-19 21:12:32
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 10 个回答

梦尘逸

新虫 (初入文坛)

自己顶下,跪求意见
2楼2012-11-19 16:29:25
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

nono2009

超级版主 (文学泰斗)

No gains, no pains.

优秀区长优秀区长优秀区长优秀区长优秀版主

【答案】应助回帖

感谢参与,应助指数 +1
编辑让你改,说明希望很大。好好改,不能改也好好解释
3楼2012-11-19 19:42:59
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

xianjin1985

铁杆木虫 (著名写手)

【答案】应助回帖

感谢参与,应助指数 +1
感觉应该会有机会被接受,只要认真去改,并且对第二个审稿人的意见适当接受,看自己怎么改了吧
4楼2012-11-19 20:15:38
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[考研] 一志愿西安交通大学材料工程专业 282分求调剂 +3 枫桥ZL 2026-03-18 3/150 2026-03-19 10:15 by 功夫疯狂
[考研] 【同济软件】软件(085405)考研求调剂 +3 2026eternal 2026-03-18 3/150 2026-03-18 19:09 by 搏击518
[考研] 08工科 320总分 求调剂 +5 梨花珞晚风 2026-03-17 5/250 2026-03-18 14:49 by haxia
[考研] 材料与化工一志愿南昌大学327求调剂推荐 +8 Ncdx123456 2026-03-13 9/450 2026-03-18 14:40 by haxia
[考研] 环境工程调剂 +8 大可digkids 2026-03-16 8/400 2026-03-18 09:36 by zhukairuo
[考博] 26博士申请 +3 1042136743 2026-03-17 3/150 2026-03-17 23:30 by 轻松不少随
[考研] 332求调剂 +6 Zz版 2026-03-13 6/300 2026-03-17 17:03 by ruiyingmiao
[考研] 考研调剂 +3 淇ya_~ 2026-03-17 5/250 2026-03-17 09:25 by Winj1e
[考研] 11408 一志愿西电,277分求调剂 +3 zhouzhen654 2026-03-16 3/150 2026-03-17 07:03 by laoshidan
[考研] 药学383 求调剂 +3 药学chy 2026-03-15 4/200 2026-03-16 20:51 by 元子^0^
[考研] 070300化学学硕求调剂 +6 太想进步了0608 2026-03-16 6/300 2026-03-16 16:13 by kykm678
[考研] 294求调剂 +3 Zys010410@ 2026-03-13 4/200 2026-03-15 10:59 by zhq0425
[考研] 328求调剂 +3 5201314Lsy! 2026-03-13 6/300 2026-03-14 15:31 by hyswxzs
[考研] 297求调剂 +4 学海漂泊 2026-03-13 4/200 2026-03-14 11:51 by 热情沙漠
[考研] 材料与化工(0856)304求B区调剂 +6 邱gl 2026-03-12 7/350 2026-03-13 23:24 by 邱gl
[考研] 26调剂/材料科学与工程/总分295/求收留 +9 2026调剂侠 2026-03-12 9/450 2026-03-13 20:46 by 18595523086
[考研] 328化工专硕求调剂 +4 。,。,。,。i 2026-03-12 4/200 2026-03-13 14:44 by JourneyLucky
[考研] 308求调剂 +3 是Lupa啊 2026-03-12 3/150 2026-03-13 14:30 by 求调剂zz
[考研] 070303一志愿西北大学学硕310找调剂 +3 d如愿上岸 2026-03-13 3/150 2026-03-13 10:43 by houyaoxu
[考研] 333求调剂 +3 152697 2026-03-12 4/200 2026-03-13 07:08 by Iveryant
信息提示
请填处理意见