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梦尘逸

新虫 (初入文坛)

[求助] 求助,这样说文章能不能被接受?

本人前一段时间在international immunopharmacology上头了一篇文章,影响因子不高2.3吧,审稿意见回来了,有一个审稿人就提了3个问题,还都是小问题,基本没什么事,不过另一个审稿人却是这么说的
Reviewer #2: The authors of this study claimed that synergistic effects of blocking IL-1beta and IL-17A could suppress the rheumatoid development in CIA mouse model.  Blocking of IL-1 and IL-17signaling pathway have been shown playing function in delaying or preventing the development of rheumatoid arthritis. In this study, the authors did not point out any new information in addition to well-documented. Detailed mechanism on how those two molecules play a synergistic effect is more favored.
And there are also several other questions.
1. The whole experiment was done in DBA mice, why humanized antibodies were used? Please justify the structural similarity of both human and murine IL-1 beta and IL-17A as well as the crossreactivities of those blocking antibody.
2. In 3.4 and 3.5, as author stated, it should be ex vivo experiment but not in vitro.

求助大神们这种意见应该怎么办呢,问题严不严重啊?我最好怎么回答他,已经困扰好久了
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梦尘逸

新虫 (初入文坛)

引用回帖:
3楼: Originally posted by nono2009 at 2012-11-19 19:42:59
编辑让你改,说明希望很大。好好改,不能改也好好解释

好滴
10楼2012-11-20 11:29:18
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梦尘逸

新虫 (初入文坛)

自己顶下,跪求意见
2楼2012-11-19 16:29:25
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nono2009

超级版主 (文学泰斗)

No gains, no pains.

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【答案】应助回帖

感谢参与,应助指数 +1
编辑让你改,说明希望很大。好好改,不能改也好好解释
3楼2012-11-19 19:42:59
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xianjin1985

铁杆木虫 (著名写手)

【答案】应助回帖

感谢参与,应助指数 +1
感觉应该会有机会被接受,只要认真去改,并且对第二个审稿人的意见适当接受,看自己怎么改了吧
4楼2012-11-19 20:15:38
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